McShane P M, Schiff I, Trentham D E
JAMA. 1985 Jun 28;253(24):3555.
To investigate further whether immunity to sperm contributes to some cases of infertility in women, the production of leukocyte inhibitory factor by blood mononuclear cells challenged with human sperm in vitro was measured in women with infertility associated with poor results of postcoital tests or long-term unexplained infertility. Five (36%) of 14 infertile patients but none of nine fertile volunteers responded significantly to sperm in this assay. No study subject had serum IgG or IgM antibodies to sperm detected. These data provide additional evidence consistent with the possibility that cellular immunity to sperm-specific antigen(s) functions in the primary pathogenesis of infertility in some women.
为了进一步研究对精子的免疫是否导致某些女性的不孕情况，对性交后试验结果不佳或长期不明原因不孕的女性，检测了体外用人精子刺激的血液单核细胞产生白细胞抑制因子的情况。在该检测中，14名不孕患者中有5名（36%）对精子有显著反应，而9名有生育能力的志愿者均无此反应。未检测到研究对象的血清中有针对精子的IgG或IgM抗体。这些数据提供了更多证据，支持对精子特异性抗原的细胞免疫在某些女性不孕的原发性发病机制中起作用这一可能性。
