Postgraduate Program in Public Health, School of Medicine, Universidade Federal de Minas Gerais, Brazil.
Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Brazil.
Public Health Nutr. 2020 Feb;23(3):506-514. doi: 10.1017/S1368980019002490. Epub 2019 Oct 7.
To investigate the association between the intake of selected food groups and beverages and serum uric acid (UA).
Cross-sectional study using the baseline data (2008-2010) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Food intake was assessed by food frequency questionnaire with 114 items. Linear and logistic regressions investigated the associations between the daily intake of each food group (servings/d) and UA (mg/dl) and hyperuricemia (UA ≥ 6·8 mg/dl), respectively. All the analyses were adjusted for potential confounders, energy intake and all food groups.
Teaching and research institutions from six Brazilians states.
The participants were 14 320 active and retired civil servants, aged 35-74 years.
Higher intake of dairy products was associated with lower serum UA levels in both sexes, with a statistical dose-response gradient. High meat intake was associated with high UA only in women, and high intake of organ meats, in men. Intake of fish and fruits, vegetables and legumes were not associated with serum UA. In men, moderate and high intake of alcoholic beverages, specifically beer and spirits, but not wine, increased UA. In women, only high intake of alcoholic beverages, specifically beer, was associated with increased serum UA. Similar associations were seen for hyperuricemia.
Results suggest a potential beneficial role of dairy products consumption on UA levels. The association between alcohol intake and UA differed according to type of beverage and between sexes. Results reinforce the need to consider the whole diet in the analysis and to conduct sex stratified analysis.
研究特定食物组和饮料的摄入与血清尿酸（UA）之间的关系。
使用巴西成人健康纵向研究（ELSA-Brasil）的基线数据（2008-2010 年）进行横断面研究。通过包含 114 项的食物频率问卷评估食物摄入。线性和逻辑回归分别调查了每日每种食物组（份/天）的摄入量与 UA（mg/dl）和高尿酸血症（UA≥6.8mg/dl）之间的关系。所有分析均调整了潜在混杂因素、能量摄入和所有食物组。
来自巴西六个州的教学和研究机构。
参与者为 14320 名在职和退休的公务员，年龄 35-74 岁。
在男性和女性中，乳制品摄入量较高与血清 UA 水平较低相关，具有统计学剂量反应梯度。高肉类摄入量仅与女性的 UA 升高相关，而高摄入动物内脏与男性的 UA 升高相关。鱼类和水果、蔬菜和豆类的摄入量与血清 UA 无关。在男性中，适量和高量的酒精饮料，特别是啤酒和烈酒，而不是葡萄酒，会增加 UA。在女性中，只有高量的酒精饮料，特别是啤酒，与血清 UA 升高相关。高尿酸血症也存在类似的关联。
结果表明乳制品摄入对 UA 水平可能具有潜在的有益作用。酒精摄入与 UA 之间的关系因饮料类型和性别而异。结果强调了在分析中需要考虑整个饮食，并进行性别分层分析的必要性。
