Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.
Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Semin Cell Dev Biol. 2020 Apr;100:20-28. doi: 10.1016/j.semcdb.2019.09.003. Epub 2019 Oct 4.
The adult mammalian heart is incapable of clinically relevant regeneration. The regenerative deficit in adult mammalian heart contrasts with the fetal and neonatal heart, which demonstrate substantial regenerative capacity after injury. This deficiency in adult mammals is attributable to the lack of resident stem cells after birth, combined with an inability of pre-existing cardiomyocytes to complete cytokinesis. Studies of neonatal heart regeneration in mammals suggest that latent regenerative potential can be re-activated. Dissecting the cellular and molecular mechanisms that promote cardiomyocyte proliferation is key to stimulating true regeneration in adult humans. Here, we review recent advances in our understanding of cardiomyocyte proliferation that suggest molecular approaches to heart regeneration.
成年哺乳动物的心脏无法进行临床上有意义的再生。成年哺乳动物的心脏在再生方面存在缺陷，而胎儿和新生儿的心脏在受到损伤后具有很强的再生能力。哺乳动物成年后缺乏驻留干细胞，加上原有心肌细胞无法完成胞质分裂，这是造成成年哺乳动物心脏再生能力缺陷的原因。对哺乳动物新生儿心脏再生的研究表明，潜在的再生能力可以被重新激活。解析促进心肌细胞增殖的细胞和分子机制是刺激成年人类真正再生的关键。在这里，我们回顾了最近在理解心肌细胞增殖方面的进展，这些进展为心脏再生提供了分子方法。
