Gastroenterology Service, Mendaro Hospital, Mendaro, Spain; Gastroenterology Service, Donostia University Hospital, Donostia, Spain.
Clinical Epidemiology Unit, CASPe, CIBER-ESP, Donostia University Hospital, Donostia, Spain.
Ann Hepatol. 2020 Jan-Feb;19(1):31-35. doi: 10.1016/j.aohep.2019.07.014. Epub 2019 Sep 24.
We aimed to study the liver iron concentration in patients referred for hyperferritinemia to six hospitals in the Basque Country and to determine if there were differences between patients with or without metabolic syndrome.
Metabolic syndrome was defined by accepted criteria. Liver iron concentration was determined by magnetic resonance imaging.
We obtained the data needed to diagnose metabolic syndrome in 276 patients; a total of 135 patients (49%), 115/240 men (48%), and 20/36 women (55.6%) presented metabolic syndrome. In all 276 patients, an MRI for the determination of liver iron concentration (mean±SD) was performed. The mean liver iron concentration was 30.83±19.38 for women with metabolic syndrome, 38.84±25.50 for men with metabolic syndrome, and 37.66±24.79 (CI 95%; 33.44-41.88) for the whole metabolic syndrome group. In 141 patients (51%), metabolic syndrome was not diagnosed: 125/240 were men (52%) and 16/36 were women (44.4%). The mean liver iron concentration was 34.88±16.18 for women without metabolic syndrome, 44.48±38.16 for men without metabolic syndrome, and 43.39±36.43 (CI 95%, 37.32-49.46) for the whole non-metabolic syndrome group. Comparison of the mean liver iron concentration from both groups (metabolic syndrome vs non-metabolic syndrome) revealed no significant differences (p=0.12).
Patients with hyperferritinemia and metabolic syndrome presented a mildly increased mean liver iron concentration that was not significantly different to that of patients with hyperferritinemia and non-metabolic syndrome.
我们旨在研究六个巴斯克地区医院因高血铁蛋白而就诊的患者的肝脏铁浓度，并确定其是否存在代谢综合征患者和非代谢综合征患者之间的差异。
采用公认的标准定义代谢综合征。通过磁共振成像确定肝脏铁浓度。
我们获得了 276 名患者诊断代谢综合征所需的数据；共有 135 名患者（49%）、115/240 名男性（48%）和 20/36 名女性（55.6%）患有代谢综合征。在所有 276 名患者中，均进行了用于确定肝脏铁浓度的磁共振成像（平均值±标准差）。患有代谢综合征的女性的平均肝脏铁浓度为 30.83±19.38，患有代谢综合征的男性为 38.84±25.50，整个代谢综合征组为 37.66±24.79（95%CI；33.44-41.88）。在 141 名（51%）未诊断出代谢综合征的患者中，125/240 名男性（52%）和 16/36 名女性（44.4%）。未患有代谢综合征的女性的平均肝脏铁浓度为 34.88±16.18，未患有代谢综合征的男性为 44.48±38.16，整个非代谢综合征组为 43.39±36.43（95%CI；37.32-49.46）。比较两组（代谢综合征组与非代谢综合征组）的平均肝脏铁浓度，发现无显著差异（p=0.12）。
患有高血铁蛋白和代谢综合征的患者的平均肝脏铁浓度略有升高，但与患有高血铁蛋白和非代谢综合征的患者的平均肝脏铁浓度无显著差异。
