Castiella Agustin, Zapata Eva, Zubiaurre Leire, Iribarren Arantxa, Alústiza Jose M, Otazua Pedro, Salvador Emma, Emparanza José I
Gastroenterology Service, Mendaro Hospital, Mendaro, Spain.
Radiology Service, Osatek Donostia, Donostia, Spain.
Ann Hepatol. 2016 Jun 1;15(4):540-544. doi: 10.5604/16652681.1202947.
Background & aims. Hyperferritinemia (HF) is frequently present in patients with metabolic syndrome (MS). MS associated with HF is named dysmetabolic hyperferritinemia (DH). There are some publications that propose that DH is associated with a raised liveriron concentration (LIC). We studied the LIC in patients referred for HF to a secondary hospital to determine if there are differences between patients with or without MS.
We conducted a prospective study of 132 consecutive patients with HF from January to December 2010. The MS was defined by the International Diabetes Federation criteria (2005). LIC was determined by Magnetic resonance imaging (MRI).
The number of patients for which there was enough data to determine MS was 97, out of which 54 had MS and 43 had no MS (NMS). In 54/97 patients, MRI for LIC determination was performed. From the MS group, 44 were men (27 underwent MRI) and 10 women (9 MRI). The mean LIC was 27.83 ± 20.90 ?mol/g for the MS group. In the NMS group, 36 were men (13 MRI), and 7 women (5 MRI). In 18 patients from the NMS group, LIC was determined by MRI. The mean LIC was 33.16 ± 19.61 ?mol/g in the NMS group. We compared the mean values of LIC from both groups (MS vs. NMS) and no significant differences were found (p = 0.067).
Patients with DH present a mean LIC within normal values and their values do not differ from those of patients with HF but without MS.
背景与目的。高铁蛋白血症（HF）在代谢综合征（MS）患者中经常出现。与HF相关的MS被称为代谢异常性高铁蛋白血症（DH）。有一些出版物提出，DH与肝脏铁浓度（LIC）升高有关。我们研究了转诊至二级医院的HF患者的LIC，以确定患有或未患有MS的患者之间是否存在差异。
我们对2010年1月至12月连续收治的132例HF患者进行了一项前瞻性研究。MS由国际糖尿病联盟标准（2005年）定义。LIC通过磁共振成像（MRI）测定。
有足够数据确定MS的患者数量为97例，其中54例患有MS，43例未患有MS（NMS）。在54/97例患者中进行了用于LIC测定的MRI检查。MS组中，男性44例（27例接受MRI检查），女性10例（9例接受MRI检查）。MS组的平均LIC为27.83±20.90μmol/g。NMS组中，男性36例（13例接受MRI检查），女性7例（5例接受MRI检查）。NMS组中有18例患者通过MRI测定了LIC。NMS组的平均LIC为33.16±19.61μmol/g。我们比较了两组（MS组与NMS组）LIC的平均值，未发现显著差异（p = 0.067）。
DH患者的平均LIC在正常范围内，其值与患有HF但未患有MS的患者的值没有差异。
