Department of Psychology and Logopedics, University of Helsinki, P.O. Box 21, Helsinki 00014, Finland.
Department of Psychology and Logopedics, University of Helsinki, P.O. Box 21, Helsinki 00014, Finland.
Psychiatry Res. 2019 Nov;281:112574. doi: 10.1016/j.psychres.2019.112574. Epub 2019 Sep 25.
We investigated ADHD symptoms and life outcomes in adulthood and their association with childhood ADHD and subthreshold symptoms in a prospectively followed cohort with perinatal risks. We identified participants with childhood ADHD (cADHD, n = 37), subthreshold symptoms defined as attention problems (cAP, n = 64), and no ADHD or cAP (Non-cAP, n = 217). We compared the groups and a control group with no perinatal risks (n = 64) on self-reported ADHD symptoms, executive dysfunction, and life outcomes in adulthood. At age 40, 21.6% of the cADHD, 6.3% of the cAP, 6.0% of the Non-cAP group, and 1.6% of the controls reached a screener cutoff for possible ADHD. The cADHD group had lower educational level, more ADHD symptoms and executive dysfunction, and higher rates of drug use than the other groups. Childhood ADHD associated with perinatal risks persists into midlife whereas childhood subthreshold ADHD symptoms in this cohort were not associated with negative outcomes in adulthood.
我们在一个具有围产期风险的前瞻性队列中研究了成年期的注意力缺陷多动障碍（ADHD）症状和生活结局及其与儿童期 ADHD 和亚临床症状的关系。我们确定了患有儿童期 ADHD（cADHD，n=37）、定义为注意力问题的亚临床症状（cAP，n=64）和无 ADHD 或 cAP 的参与者（非 cAP，n=217）。我们比较了各组和无围产期风险的对照组（n=64）在成年期的自我报告 ADHD 症状、执行功能和生活结局。在 40 岁时，cADHD 组、cAP 组、非 cAP 组和对照组的可能 ADHD 筛查截定点分别为 21.6%、6.3%、6.0%和 1.6%。cADHD 组的受教育程度较低，ADHD 症状和执行功能障碍较多，药物使用率也较高。具有围产期风险的儿童期 ADHD 持续到中年，而该队列中的儿童期亚临床 ADHD 症状与成年期的不良结局无关。
