Neuro and Vascular Guidance, Buchmann Institute for Molecular Life Sciences, University of Frankfurt, D-60438 Frankfurt am Main, Germany; email:
Institute of Cell Biology and Neuroscience, University of Frankfurt, D-60438 Frankfurt am Main, Germany.
Annu Rev Cell Dev Biol. 2019 Oct 6;35:615-635. doi: 10.1146/annurev-cellbio-100818-125142.
Molecular cross talk between the nervous and vascular systems is necessary to maintain the correct coupling of organ structure and function. Molecular pathways shared by both systems are emerging as major players in the communication of the neuronal compartment with the endothelium. Here we review different aspects of this cross talk and how vessels influence the development and homeostasis of the nervous system. Beyond the classical role of the vasculature as a conduit to deliver oxygen and metabolites needed for the energy-demanding neuronal compartment, vessels emerge as powerful signaling systems that control and instruct a variety of cellular processes during the development of neurons and glia, such as migration, differentiation, and structural connectivity. Moreover, a broad spectrum of mild to severe vascular dysfunctions occur in various pathologies of the nervous system, suggesting that mild structural and functional changes at the neurovascular interface may underlie cognitive decline in many of these pathological conditions.
神经和血管系统之间的分子串扰对于维持器官结构和功能的正确偶联是必要的。这两个系统共享的分子途径正在成为神经元与内皮细胞之间通讯的主要参与者。在这里，我们回顾了这种串扰的不同方面，以及血管如何影响神经系统的发育和稳态。除了血管作为输送神经元这一耗能部位所需的氧气和代谢物的导管的经典作用外，血管还作为强大的信号系统出现，在神经元和神经胶质的发育过程中控制和指导多种细胞过程，如迁移、分化和结构连接。此外，在神经系统的各种病变中，广泛存在从轻度到重度的血管功能障碍，这表明神经血管界面的轻度结构和功能变化可能是许多病理情况下认知能力下降的基础。
