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Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort.利用弗雷明汉心脏研究后代队列的数据评估中年人口统计学和生活方式危险因素与痴呆的关系。
J Alzheimers Dis. 2018;63(3):1119-1127. doi: 10.3233/JAD-170917.
2
Marriage and risk of dementia: systematic review and meta-analysis of observational studies.婚姻与痴呆风险:观察性研究的系统评价和荟萃分析。
J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):231-238. doi: 10.1136/jnnp-2017-316274. Epub 2017 Nov 28.
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A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012.2000年与2012年美国痴呆症患病率比较
JAMA Intern Med. 2017 Jan 1;177(1):51-58. doi: 10.1001/jamainternmed.2016.6807.
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Sex differences in cognitive impairment in Alzheimer's disease.阿尔茨海默病认知障碍的性别差异。
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Marital status and risk of dementia: a nationwide population-based prospective study from Sweden.婚姻状况与痴呆症风险:一项基于瑞典全国人口的前瞻性研究。
BMJ Open. 2016 Jan 4;6(1):e008565. doi: 10.1136/bmjopen-2015-008565.
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Marked gender differences in progression of mild cognitive impairment over 8 years.8年间轻度认知障碍进展存在显著的性别差异。
Alzheimers Dement (N Y). 2015 Sep 1;1(2):103-110. doi: 10.1016/j.trci.2015.07.001.
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Marital Quality and Negative Experienced Well-Being: An Assessment of Actor and Partner Effects Among Older Married Persons.婚姻质量与负面体验幸福感:对老年已婚者中行为者效应和伴侣效应的评估
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Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging.在梅奥诊所衰老研究中预测轻度认知障碍的风险。
Neurology. 2015 Apr 7;84(14):1433-42. doi: 10.1212/WNL.0000000000001437. Epub 2015 Mar 18.
9
Marital Status and Cognitive Impairment among Community-Dwelling Chinese Older Adults: The Role of Gender and Social Engagement.中国社区居住老年人的婚姻状况与认知障碍:性别与社会参与的作用
Dement Geriatr Cogn Dis Extra. 2014 Oct 14;4(3):375-84. doi: 10.1159/000358584. eCollection 2014 Sep.
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Bad marriage, broken heart? Age and gender differences in the link between marital quality and cardiovascular risks among older adults.糟糕的婚姻会导致心碎吗?老年人婚姻质量与心血管风险之间关联的年龄和性别差异。
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婚姻状况与美国的认知障碍:来自国家健康与老龄化趋势研究的证据。

Marital status and cognitive impairment in the United States: evidence from the National Health and Aging Trends Study.

机构信息

Department of Sociology, Michigan State University, East Lansing, MI.

Department of Sociology, Michigan State University, East Lansing, MI.

出版信息

Ann Epidemiol. 2019 Oct;38:28-34.e2. doi: 10.1016/j.annepidem.2019.08.007. Epub 2019 Aug 21.

DOI:10.1016/j.annepidem.2019.08.007
PMID:31591027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6812624/
Abstract

PURPOSE

We provide population-based longitudinal evidence of marital status differences in the risk of cognitive impairment and dementia in the United States.

METHODS

Data were from the longitudinal National Health and Aging Trends Study, 2011-2018. The sample included 7508 respondents aged 65 years and older who contributed 25,897 person-year records. We estimated discrete-time hazard models to predict the risk of dementia and cognitive impairment, not dementia (CIND), as well as impairment in three major cognitive domains: memory, orientation, and executive function.

RESULTS

Relative to their married counterparts, divorced and widowed elders had higher odds of dementia and CIND, as well as higher odds of impairment in each of the cognitive domains. Never-married elders had higher odds of impairment in memory and orientation than their married counterparts but did not differ significantly in the odds of impaired executive function, dementia, or CIND. Cohabiting elders did not differ significantly from married respondents on any measure of cognitive impairment. We found no gender differences in the associations between marital status and the measures of cognitive impairment.

CONCLUSIONS

Marital status is a potentially important but overlooked social risk/protective factor for cognitive impairment. Divorced and widowed older adults are particularly vulnerable to cognitive impairment.

摘要

目的

我们提供了基于人群的纵向证据,表明在美国,婚姻状况的不同与认知障碍和痴呆的风险有关。

方法

数据来自于纵向的国家健康与老龄化趋势研究,时间范围为 2011 年至 2018 年。样本包括 7508 名年龄在 65 岁及以上的受访者,他们提供了 25897 人年的记录。我们估计了离散时间风险模型,以预测痴呆和认知障碍但非痴呆(CIND)以及三个主要认知领域(记忆、定向和执行功能)受损的风险。

结果

与已婚同龄人相比,离婚和丧偶的老年人患痴呆和 CIND 的几率更高,每个认知领域受损的几率也更高。从未结婚的老年人在记忆和定向方面受损的几率高于已婚同龄人,但在执行功能、痴呆或 CIND 受损的几率方面没有显著差异。与已婚受访者相比,同居的老年人在任何认知障碍衡量标准上都没有显著差异。我们没有发现性别差异在婚姻状况与认知障碍衡量标准之间的关联。

结论

婚姻状况是认知障碍的一个潜在重要但被忽视的社会风险/保护因素。离婚和丧偶的老年人尤其容易受到认知障碍的影响。