Holden Ciara, Bignell Lauren, Mukhopadhyay Somnath, Jones Christina
Academic Department of Paediatrics, Royal Alexandra Children's Hospital, Brighton & Sussex Medical School, Brighton, BN2 5BE, UK.
Academic Department of General Practice, Queen Mary University of London, Mile End Rd, London, E1 4NS, UK.
Per Med. 2019 Sep;16(5):409-420. doi: 10.2217/pme-2018-0151. Epub 2019 Oct 8.
The integration of personalized medicine (PM) into mainstream healthcare will only be successful if the public understands and supports this change. The aim was to understand the public perception of the barriers and facilitators towards the use of PM. A systematic review of the literature was conducted within six databases from 2006 to 2018. Twenty-one studies with 9507 participants were included. The key themes were familiarity and willingness to use PM, perceived benefits and perceived risks of PM. The review shows that the public is generally enthusiastic about the introduction of PM, although this should be interpreted with cautious optimism due to participants having a limited familiarity of the underlying principles of PM. The study defines areas where progress can be made to enhance this understanding and addresses legitimate concerns.
只有当公众理解并支持这一变革时，将个性化医疗（PM）融入主流医疗保健才会成功。目的是了解公众对使用PM的障碍和促进因素的看法。在2006年至2018年期间，对六个数据库进行了文献系统综述。纳入了21项研究，共9507名参与者。关键主题包括对PM的熟悉程度和使用意愿、PM的感知益处和感知风险。综述表明，公众总体上对引入PM持热情态度，不过鉴于参与者对PM基本原则的熟悉程度有限，对此应持谨慎乐观的态度。该研究确定了可以取得进展以增进这种理解的领域，并解决了合理关切的问题。
