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基于人体磁场和芯片器官的磁性纳米颗粒在癌症诊断与治疗中的潜力

The Potential of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer Based on Body Magnetic Field and Organ-on-the-Chip.

作者信息

Alirezaie Alavijeh Ali, Barati Mohammad, Barati Meisam, Abbasi Dehkordi Hussein

机构信息

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.

Department of Applied Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.

出版信息

Adv Pharm Bull. 2019 Aug;9(3):360-373. doi: 10.15171/apb.2019.043. Epub 2019 Aug 1.

Abstract

Cancer is an abnormal cell growth which tends to proliferate in an uncontrolled way and, in some cases, leads to metastasis. If cancer is left untreated, it can immediately cause death. The use of magnetic nanoparticles (MNPs) as a drug delivery system will enable drugs to target tissues and cell types precisely. This study describes usual strategies and consideration for the synthesis of MNPs and incorporates payload drug on MNPs. They have advantages such as visual targeting and delivering which will be discussed in this review. In addition, we considered body magnetic field to make drug delivery process more effective and safer by the application of MNPs and tumor-on-chip.

摘要

癌症是一种异常的细胞生长,往往以不受控制的方式增殖,在某些情况下会导致转移。如果癌症不加以治疗,会立即导致死亡。使用磁性纳米颗粒(MNPs)作为药物递送系统将使药物能够精确地靶向组织和细胞类型。本研究描述了合成MNPs的常用策略和注意事项,并将负载药物整合到MNPs上。它们具有视觉靶向和递送等优点,将在本综述中进行讨论。此外,我们考虑利用人体磁场,通过应用MNPs和芯片上肿瘤来使药物递送过程更有效、更安全。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a0/6773933/63053dde49e5/apb-9-360-g001.jpg

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