Huang Jing, Li Yuancheng, Orza Anamaria, Lu Qiong, Guo Peng, Wang Liya, Yang Lily, Mao Hui
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Adv Funct Mater. 2016 Jun 14;26(22):3818-3836. doi: 10.1002/adfm.201504185. Epub 2016 Feb 5.
With rapid advances in nanomedicine, magnetic nanoparticles (MNPs) have emerged as a promising theranostic tool in biomedical applications, including diagnostic imaging, drug delivery and novel therapeutics. Significant preclinical and clinical research has explored their functionalization, targeted delivery, controllable drug release and image-guided capabilities. To further develop MNPs for theranostic applications and clinical translation in the future, we attempt to provide an overview of the recent advances in the development and application of MNPs for drug delivery, specifically focusing on the topics concerning the importance of biomarker targeting for personalized therapy and the unique magnetic and contrast-enhancing properties of theranostic MNPs that enable image-guided delivery. The common strategies and considerations to produce theranostic MNPs and incorporate payload drugs into MNP carriers are described. The notable examples are presented to demonstrate the advantages of MNPs in specific targeting and delivering under image guidance. Furthermore, current understanding of delivery mechanisms and challenges to achieve efficient therapeutic efficacy or diagnostic capability using MNP-based nanomedicine are discussed.
随着纳米医学的迅速发展，磁性纳米颗粒（MNPs）已成为生物医学应用中一种有前景的诊疗工具，包括诊断成像、药物递送和新型治疗方法。大量的临床前和临床研究已经探索了它们的功能化、靶向递送、可控药物释放和图像引导能力。为了在未来进一步开发用于诊疗应用和临床转化的MNPs，我们试图概述MNPs在药物递送开发和应用方面的最新进展，特别关注与生物标志物靶向用于个性化治疗的重要性以及诊疗MNPs能够实现图像引导递送的独特磁性和造影增强特性相关的主题。描述了制备诊疗MNPs并将负载药物纳入MNP载体的常见策略和注意事项。列举了显著的例子以证明MNPs在图像引导下进行特异性靶向和递送方面的优势。此外，还讨论了目前对使用基于MNP的纳米医学实现有效治疗效果或诊断能力的递送机制和挑战的理解。
