磁性纳米颗粒在癌症诊断、药物递送与治疗中的应用
Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment.
作者信息
Wu Meijia, Huang Shengwu
机构信息
Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 311402, P.R. China.
出版信息
Mol Clin Oncol. 2017 Nov;7(5):738-746. doi: 10.3892/mco.2017.1399. Epub 2017 Aug 28.
Abstract
In recent years, magnetic nanoparticles (MNPs) have demonstrated marked progress in the field of oncology. General nanoparticles are widely used in tumor targeting, and the intrinsic magnetic property of MNPs makes them the most promising nanomaterial to be used as contrast agents for magnetic resonance imaging (MRI) and induced magnetic hyperthermia. The properties of MNPs are fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location by application of an external magnetic field. Early diagnosis of cancer may be achieved by MRI, therefore, individualized treatment may be combined with MRI, so as to achieve the precise definition and appropriate treatment. In the present review, research on MNPs in cancer diagnosis, drug delivery and treatment has been summarized. Furthermore, the future perspectives and challenges of MNPs in the field of oncology are also discussed.
摘要
近年来，磁性纳米颗粒（MNPs）在肿瘤学领域已取得显著进展。一般的纳米颗粒广泛应用于肿瘤靶向，而MNPs的固有磁性使其成为用作磁共振成像（MRI）造影剂和诱导磁热疗最具前景的纳米材料。当MNPs用作药物递送剂时，其特性得到了充分利用，通过施加外部磁场，药物可靶向至所需的特定位置。MRI可实现癌症的早期诊断，因此，个体化治疗可与MRI相结合，从而实现精确诊断和恰当治疗。在本综述中，总结了MNPs在癌症诊断、药物递送和治疗方面的研究。此外，还讨论了MNPs在肿瘤学领域的未来前景和挑战。
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