Mariko Rinang, Darwin Eryati, Yanwirasti Yanwirasti, Hadinegoro Sri Rezeki
Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia.
Department of Pediatrics, Faculty of Medicine, Andalas University, General Hospital of Dr M. Djamil, Padang, Indonesia.
Open Access Maced J Med Sci. 2019 Jul 25;7(14):2277-2281. doi: 10.3889/oamjms.2019.602. eCollection 2019 Jul 30.
Dengue virus infection is an infectious disease caused by the dengue virus and transmitted by the Aedes aegypti mosquito. Dengue virus (DEN-V) consists of 4 serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4. The most feared result of DHF is death. Death in children is caused by hypovolemic shock due to plasma leakage from intravascular to extravascular space due to endothelial dysfunction.
This study aims to analyse difference in sVE-Cadherin levels in Dengue Hemorrhagic Fever (DHF) with and without shock.
The method of taking samples is consecutive sampling, namely the research subjects obtained based on the order of entry in the hospital with a comparative cross-sectional design. From the results of the calculation using the sample formula, the sample size for each group is set at 32 people. So that the total sample size used for both groups is 64 people. The serum sVE-Cadherin levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant.
The result showed that there was no difference in mean sVE-Cadherin levels between DHF patients with shock and without shock (p > 0.05).
This study concluded that there was no difference in mean of sVE-Cadherin level in DHF patients with shock and without shock.
登革病毒感染是一种由登革病毒引起、通过埃及伊蚊传播的传染病。登革病毒（DEN-V）由4种血清型组成，即DEN-1、DEN-2、DEN-3和DEN-4。登革出血热最可怕的后果是死亡。儿童死亡是由于内皮功能障碍导致血浆从血管内渗漏到血管外空间，进而引起低血容量性休克所致。
本研究旨在分析有休克和无休克的登革出血热（DHF）患者中可溶性血管内皮钙黏蛋白（sVE-Cadherin）水平的差异。
采样方法为连续抽样，即基于患者入院顺序获得研究对象，采用比较性横断面设计。根据样本公式计算结果，每组样本量设定为32人。因此，两组使用的总样本量为64人。采用酶联免疫吸附测定（ELISA）法检测血清sVE-Cadherin水平。使用的统计检验为独立样本t检验。p值<0.05被认为具有统计学意义。
结果显示，有休克和无休克的登革出血热患者的平均sVE-Cadherin水平无差异（p>0.05）。
本研究得出结论，有休克和无休克的登革出血热患者的平均sVE-Cadherin水平无差异。
