Guzmán M G, Kouri G P, Bravo J, Soler M, Vazquez S, Morier L
Instituto de Medicina Tropical Pedro Kouri, Habana, Cuba.
Am J Trop Med Hyg. 1990 Feb;42(2):179-84. doi: 10.4269/ajtmh.1990.42.179.
In Cuba, 2 epidemics of dengue virus occurred: 1 caused by DEN-1 in 1977 and 1 caused by DEN-2 in 1981. The latter was associated with cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). To study viral risk factors for DHF/DSS, a retrospective seroepidemiological survey was conducted in Cerro, a densely populated district in Havana City. The prevalence of plaque reduction neutralizing antibodies to DEN-1 and DEN-2 viruses was measured in 1,295 individuals (children and adults). Of these, 43.7% were immune to DEN-1 virus and 23.6% to DEN-2 virus. Of those individuals who were immune, 26.1% were immune to DEN-1 virus only, 6% to DEN-2 virus only, and 17.6% to both viruses. The DEN-2 virus infection rate in DEN-1 immune individuals was 3.8 times higher than in non-immune individuals. The 5 DHF/DSS cases in the sample had evidence of DEN-1 virus plus DEN-2 virus infections. Three were children and 2 were young adults. No cases were found in individuals infected with DEN-1 virus or DEN-2 virus only. Children infected by DEN-1 virus followed by DEN-2 virus had a high risk of acquiring DHF/DSS. Blacks and whites were equally infected with DEN-1 and DEN-2 viruses.
在古巴，发生了两起登革热病毒疫情：一次是1977年由1型登革病毒引起，另一次是1981年由2型登革病毒引起。后者与登革出血热/登革休克综合征（DHF/DSS）病例相关。为了研究DHF/DSS的病毒风险因素，在哈瓦那市人口密集的塞罗区进行了一项回顾性血清流行病学调查。对1295名个体（儿童和成人）测量了针对1型登革病毒和2型登革病毒的蚀斑减少中和抗体的流行率。其中，43.7%的人对1型登革病毒免疫，23.6%的人对2型登革病毒免疫。在这些免疫个体中，26.1%仅对1型登革病毒免疫，6%仅对2型登革病毒免疫，17.6%对两种病毒都免疫。1型登革病毒免疫个体中的2型登革病毒感染率比非免疫个体高3.8倍。样本中的5例DHF/DSS病例有1型登革病毒加2型登革病毒感染的证据。3例是儿童，2例是年轻人。仅感染1型登革病毒或2型登革病毒的个体中未发现病例。先感染1型登革病毒后感染2型登革病毒的儿童患DHF/DSS的风险很高。黑人和白人感染1型登革病毒和2型登革病毒的情况相同。
