Tarini Ni Made Adi, Setiabudy Marta, Susilawathi N M, Fatmawati Nnd, Mayura Ipb, Darwinata E A, Sudiariani Nka
Department of Microbiology, Faculty of Medical and Health Sciences Udayana University, Denpasar, Bali, Indonesia.
Department of Neurology, Faculty of Medical and Health Sciences Udayana University, Denpasar, Bali, Indonesia.
Open Access Maced J Med Sci. 2019 Jul 25;7(14):2309-2312. doi: 10.3889/oamjms.2019.619. eCollection 2019 Jul 30.
is an emerging zoonotic pathogen. This bacterium commonly causes meningitis in human and is often associated with hearing and vestibular dysfunction. tends to be misidentified, leading to under-diagnosis.
A previously healthy 50-year-old man was admitted to one of the district hospitals in Bali Province, Indonesia, due to meningitis. He had a history of consuming homemade raw pork product two days before the onset of illness. Streptococcus mitis was identified from the cerebrospinal fluid culture by using VITEX 2 COMPACT (Biomeriuex) with a 99% probability score. This patient had clinical symptoms and risk factor identical to infection. Therefore, we performed confirmation tests for the cerebrospinal fluid by PCR (using primer specific for and ) and sequencing of those PCR products. Both of the confirmation tests showed a positive result for .
There are few reports of infections in Indonesia, but we believe that the cases in Indonesia, especially Bali, are not uncommon. The under-reported cases are perhaps due to the difficulties in differentiating from other Streptococcus species by culture method, particularly . Therefore, confirmation by PCR is necessary.
是一种新出现的人畜共患病原体。这种细菌通常会导致人类患脑膜炎，并且常常与听力和前庭功能障碍有关。往往会被误诊，导致诊断不足。
一名50岁的既往健康男性因脑膜炎入住印度尼西亚巴厘省的一家地区医院。他在发病前两天有食用自制生猪肉制品的病史。使用VITEX 2 COMPACT（生物梅里埃公司）从脑脊液培养物中鉴定出缓症链球菌，概率评分为99%。该患者具有与感染相同的临床症状和危险因素。因此，我们通过PCR（使用针对的特异性引物）对脑脊液进行确认试验，并对这些PCR产物进行测序。两项确认试验均显示呈阳性结果。
在印度尼西亚，关于感染的报道很少，但我们认为在印度尼西亚，尤其是巴厘岛，这种病例并不罕见。报告不足的病例可能是由于通过培养方法难以将与其他链球菌物种区分开来，特别是。因此，有必要通过PCR进行确认。
