Hosoya Yosuke, Kobayashi Ikumi, Mizoguchi Kota, Nakada Masahisa
Department of Chemistry and Biochemistry, School of Advanced Science and Engineering , Waseda University , 3-4-1 Ohkubo , Shinjuku-ku , Tokyo 169-8555 , Japan.
Org Lett. 2019 Oct 18;21(20):8280-8284. doi: 10.1021/acs.orglett.9b03046. Epub 2019 Oct 8.
A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of CsCO, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.
描述了一种通过σ-烷基钯中间体与TIPS硫醚反应进行的钯催化碳硫键化反应。发现使用碳酸铯、(IPr)Pd(烯丙基)Cl和TIPS硫醚是通过σ-烷基钯中间体反应高产率获得烷基芳基和二烷基硫化物的关键。所开发的反应适用于广泛的底物和硫醇。
