Rex D K, Bosron W F, Smialek J E, Li T K
Alcohol Clin Exp Res. 1985 Mar-Apr;9(2):147-52. doi: 10.1111/j.1530-0277.1985.tb05540.x.
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isoenzyme phenotypes were determined in autopsy liver samples from 50 North American Indians from New Mexico. Forty-six of the 50 livers had sufficient ADH activity to allow phenotyping at the ADH2 and ADH3 loci. All 46 livers possessed the "typical" ADH2 1-1 phenotype. The frequency of the ADH3(2) allele was 0.59 and is the highest thus far reported in any racial population. All 50 livers possessed the ALDH I isoenzyme which exhibits the greatest anodic mobility on starch gel electrophoresis at pH 7.6. The results show that ADH and ALDH phenotypes among American Indians living in New Mexico are very similar to those of Caucasian populations and quite different from those of Orientals.
测定了来自新墨西哥州的50名北美印第安人尸检肝脏样本中的乙醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）同工酶表型。50个肝脏中的46个具有足够的ADH活性，以便在ADH2和ADH3位点进行表型分析。所有46个肝脏都具有“典型的”ADH2 1-1表型。ADH3(2)等位基因的频率为0.59，是迄今为止在任何种族群体中报道的最高频率。所有50个肝脏都具有ALDH I同工酶，该同工酶在pH 7.6的淀粉凝胶电泳上表现出最大的阳极迁移率。结果表明，居住在新墨西哥州的美洲印第安人中的ADH和ALDH表型与白种人群体非常相似，与东方人群体有很大不同。
