Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.
Immunol Rev. 2019 Nov;292(1):209-224. doi: 10.1111/imr.12812. Epub 2019 Oct 8.
CD8 Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4 Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 and CD4 Tregs, and we will discuss the biology, development and induction of CD8 Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically accessible improvements notably through genetic modifications.
CD8 Tregs 已经被长期描述，并且在其表型、功能机制和与传统 CD4 Tregs 相比的抑制能力方面取得了重大进展。它们现在正处于临床应用的曙光阶段。在这篇综述中，我们将总结它们的表型特征、作用机制、CD8 和 CD4 Tregs 之间的相似性、差异和协同作用，我们将讨论 CD8 Tregs 的生物学、发育和诱导，以及它们用于临床应用的制造，考虑到开放性问题/不确定性和未来通过遗传修饰等技术上可实现的改进。
