Lakshmanan Karthik, Dehkharghani Seena, Madelin Guillaume, Brown Ryan
Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York.
Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York.
Magn Reson Med. 2020 Apr;83(4):1512-1518. doi: 10.1002/mrm.28005. Epub 2019 Oct 8.
To design and build a dual-tuned O/ H coil for direct brain oximetry at 3T.
A dual-tuned O/ H coil comprising 2 degenerate mode birdcage coils was constructed to facilitate high-sensitivity O and H imaging. In vivo O brain images were acquired in a healthy volunteer using a fermat looped orthogonally encoded trajectories sequence, together with high-resolution structural brain H images.
Natural abundance O images with a nominal resolution of 8 mm were acquired in under 20 minutes exhibiting clear delineation of the physiological O distribution. One-millimeter isotropic H structural brain images demonstrated excellent quality and anatomical detail using routine clinical imaging sequence parameters and parallel acceleration.
A dual-tuned O/ H array was constructed to enable high-sensitivity O and H imaging under standard clinical 3 T scanning conditions.
设计并构建用于3T直接脑血氧测定的双调谐O/H线圈。
构建一个由2个简并模式鸟笼线圈组成的双调谐O/H线圈，以促进高灵敏度的O和H成像。在一名健康志愿者体内，使用费马环形正交编码轨迹序列采集O脑图像，并同时采集高分辨率结构性脑H图像。
在不到20分钟的时间内采集到了标称分辨率为8毫米的自然丰度O图像，清晰显示了生理性O分布。使用常规临床成像序列参数和平行加速技术，1毫米各向同性的H结构性脑图像显示出优异的质量和解剖细节。
构建了一个双调谐O/H阵列，以在标准临床3T扫描条件下实现高灵敏度的O和H成像。
