一株携带新型KPC变体（KPC-36）的对头孢他啶/阿维巴坦耐药的肺炎克雷伯菌ST1519的基因组特征分析 - Suppr

Suppr

超能文献

Genomic characterization of a Klebsiella pneumoniae ST1519 resistant to ceftazidime/avibactam carrying a novel KPC variant (KPC-36).

作者信息

Gaibani Paolo, Ambretti Simone, Campoli Caterina, Viale PierLuigi, Re Maria Carla

机构信息

Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital, Bologna, Italy.

出版信息

Int J Antimicrob Agents. 2020 Jan;55(1):105816. doi: 10.1016/j.ijantimicag.2019.09.020. Epub 2019 Oct 5.

DOI:10.1016/j.ijantimicag.2019.09.020

PMID:31593765

Abstract

摘要

相似文献

Genomic characterization of a Klebsiella pneumoniae ST1519 resistant to ceftazidime/avibactam carrying a novel KPC variant (KPC-36).一株携带新型KPC变体（KPC-36）的对头孢他啶/阿维巴坦耐药的肺炎克雷伯菌ST1519的基因组特征分析

Int J Antimicrob Agents. 2020 Jan;55(1):105816. doi: 10.1016/j.ijantimicag.2019.09.020. Epub 2019 Oct 5.

Looking beyond ceftazidime-avibactam resistance in KPC-producing : activity of the novel meropenem-vaborbactam in combination with the old fosfomycin.超越产KPC菌株对头孢他啶-阿维巴坦的耐药性：新型美罗培南-巴罗巴坦与旧药磷霉素联合使用的活性

J Chemother. 2021 Dec;33(8):598-600. doi: 10.1080/1120009X.2021.1909939. Epub 2021 Apr 10.

Effects of KPC Variant and Porin Genotype on the Activity of Meropenem-Vaborbactam against Carbapenem-Resistant .KPC 变体和孔蛋白基因型对美罗培南-沃班坦对碳青霉烯类耐药的活性的影响。

Antimicrob Agents Chemother. 2019 Feb 26;63(3). doi: 10.1128/AAC.02048-18. Print 2019 Mar.

KPC-85, a carbapenemase-producing and ceftazidime-avibactam-resistant KPC-3 variant found in Klebsiella pneumoniae ST512 in the Netherlands.KPC-85，一种在荷兰肺炎克雷伯菌ST512中发现的产碳青霉烯酶且对头孢他啶-阿维巴坦耐药的KPC-3变体。

Int J Antimicrob Agents. 2024 Sep;64(3):107271. doi: 10.1016/j.ijantimicag.2024.107271. Epub 2024 Jul 11.

Genomic characterization of a KPC-23-producing Klebsiella pneumoniae ST258 clinical isolate resistant to ceftazidime-avibactam.产 KPC-23 肺炎克雷伯菌 ST258 临床分离株对头孢他啶-阿维巴坦耐药的基因组特征。

Clin Microbiol Infect. 2019 Jun;25(6):763.e5-763.e8. doi: 10.1016/j.cmi.2019.03.011. Epub 2019 Mar 28.

Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.耐碳青霉烯类肺炎克雷伯菌感染治疗期间因质粒介导的突变导致头孢他啶-阿维巴坦耐药的出现

Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.02097-16. Print 2017 Mar.

A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible Klebsiella pneumoniae Strain Harboring Isolated in New York City.一株耐头孢他啶-阿维巴坦、碳青霉烯类敏感的肺炎克雷伯菌的分离与鉴定：来自纽约市的报告。

mSphere. 2020 Aug 26;5(4):e00775-20. doi: 10.1128/mSphere.00775-20.

Reversion of KPC-114 to KPC-2 in ceftazidime-avibactam- resistant/meropenem-susceptible ST11 is related to low mutation rates.产碳青霉烯酶肺炎克雷伯菌 ST11 对头孢他啶-阿维巴坦耐药/美罗培南敏感的 KPC-114 向 KPC-2 的回复与低突变率有关。

Microbiol Spectr. 2024 Oct 3;12(10):e0117324. doi: 10.1128/spectrum.01173-24. Epub 2024 Aug 27.

Potency of Vaborbactam Is Less Affected than That of Avibactam in Strains Producing KPC-2 Mutations That Confer Resistance to Ceftazidime-Avibactam.产生赋予对头孢他啶-阿维巴坦耐药性的 KPC-2 突变的菌株中，沃博巴坦的效力比阿维巴坦的效力受影响更小。

Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.01936-19.

In vitro synergistic activity of meropenem/vaborbactam in combination with ceftazidime/avibactam against KPC-producing Klebsiella pneumoniae.美罗培南/巴罗巴坦与头孢他啶/阿维巴坦联合应用对产KPC肺炎克雷伯菌的体外协同活性。

J Antimicrob Chemother. 2019 May 1;74(5):1457-1459. doi: 10.1093/jac/dky557.

引用本文的文献

Exploring mutational possibilities of KPC variants to reach high level resistance to cefiderocol.探索KPC变体达到对头孢地尔高水平耐药的突变可能性。

Sci Rep. 2025 Aug 25;15(1):31312. doi: 10.1038/s41598-025-17044-8.

Genomic characterization of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) strains circulating in three university hospitals in Northern Italy over three years.三年间意大利北部三家大学医院流行的产碳青霉烯酶肺炎克雷伯菌（KPC-Kp）菌株的基因组特征。

Antimicrob Resist Infect Control. 2024 Jul 3;13(1):70. doi: 10.1186/s13756-024-01429-x.

International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe.欧洲耐碳青霉烯类肺炎克雷伯菌的国际和地区传播。

Nat Commun. 2024 Jun 14;15(1):5092. doi: 10.1038/s41467-024-49349-z.

Subinhibitory antibiotic concentrations promote the excision of a genomic island carried by the globally spread carbapenem-resistant sequence type 258.亚抑菌浓度的抗生素会促进在全球传播的碳青霉烯类耐药 258 型序列中携带的基因组岛的切除。

Microb Genom. 2023 Dec;9(12). doi: 10.1099/mgen.0.001138.

carbapenemase variants: the new threat to global public health.碳青霉烯酶变体：对全球公共健康的新威胁。

Clin Microbiol Rev. 2023 Dec 20;36(4):e0000823. doi: 10.1128/cmr.00008-23. Epub 2023 Nov 8.

Update of clinical application in ceftazidime-avibactam for multidrug-resistant Gram-negative bacteria infections.头孢他啶-阿维巴坦在多重耐药革兰氏阴性菌感染中的临床应用更新。

Infection. 2022 Dec;50(6):1409-1423. doi: 10.1007/s15010-022-01876-x. Epub 2022 Jul 4.

Increased gene expression and copy number of mutated bla lead to high-level ceftazidime/avibactam resistance in Klebsiella pneumoniae.突变 bla 基因表达和拷贝数增加导致肺炎克雷伯菌对头孢他啶/阿维巴坦高水平耐药。

BMC Microbiol. 2021 Aug 19;21(1):230. doi: 10.1186/s12866-021-02293-0.

Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri.产 KPC-2 型碳青霉烯酶的肺炎克雷伯菌临床分离株中，一种对头孢他啶-阿维巴坦耐药的 KPC-82 型碳青霉烯酶的特性研究。

Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0015021. doi: 10.1128/AAC.00150-21.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验