Fromm D
Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):938-42.
The mechanism(s) of salicylate-induced damage of the gastric mucosa is complex. The presence of acid in the lumen is essential for the occurrence of such injury. Although the absorption of salicylate is greater in the presence of acid, salicylate can selectively increase cation permeability both in the absence and presence of acid. Recent studies suggest that this permits increased diffusion of luminal acid into the tissue, which leads to major permeability changes of the mucosa. Salicylate also affects metabolic processes of the gastric mucosa, which appear to be independent of the increased diffusion of acid into the tissue also caused by salicylate. The release of histamine, which has been shown to occur in vivo as a result of mucosal damage, does not appear to intensify existing mucosal injury in an isolated system.
水杨酸酯导致胃黏膜损伤的机制很复杂。管腔内存在酸对于这种损伤的发生至关重要。虽然在有酸的情况下水杨酸酯的吸收会增加，但无论有无酸，水杨酸酯都能选择性地增加阳离子通透性。最近的研究表明，这会使管腔内的酸更多地扩散到组织中，从而导致黏膜的主要通透性变化。水杨酸酯还会影响胃黏膜的代谢过程，这似乎与水杨酸酯导致的酸向组织中扩散增加无关。组胺的释放已被证明是黏膜损伤在体内的结果，但在一个孤立的系统中，它似乎不会加剧现有的黏膜损伤。
