Department of Emergency Internal Medicine, Shanghai East Hospital, Tongji University, Shanghai 200120, China.
Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
J Zhejiang Univ Sci B. 2019;20(11):920-927. doi: 10.1631/jzus.B1900336.
Noncoding RNAs (ncRNAs) have played a critical role in cellular biological functions. Recently, some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases. Here, we briefly review several novel peptides translated by annotated ncRNAs and related key functions. In addition, we summarize the potential mechanism of bifunctional ncRNAs and propose a specific "switch" triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress. The coding properties of ncRNAs and their peptide products may provide a novel horizon in proteomic research and can be regarded as a potential therapeutic target for the treatment of various diseases.
非编码 RNA（ncRNA）在细胞生物学功能中发挥了关键作用。最近，在生物体发育和各种疾病中发现了一些源自注释 ncRNA 的肽或蛋白质。在这里，我们简要回顾了由注释 ncRNA 翻译的几种新型肽及其相关关键功能。此外，我们总结了双功能 ncRNA 的潜在机制，并提出了一个特定的“开关”，在某些刺激或细胞应激下，触发从非编码状态到编码状态的转变。ncRNA 的编码特性及其肽产物可能为蛋白质组学研究提供新的视角，并可视为治疗各种疾病的潜在治疗靶点。
