National Institute for Public Health and the Environment (RIVM) - Centre for Infectious disease control, Bilthoven, the Netherlands.
European Programme for Intervention Epidemiology Training (EPIET) and European Public Health Microbiology (EUPHEM) training programme, European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Euro Surveill. 2019 Oct;24(40). doi: 10.2807/1560-7917.ES.2019.24.40.1900157.
BackgroundRespiratory syncytial virus (RSV) is a major contributor to lower respiratory tract infections worldwide and several vaccine candidates are currently in development. Following vaccine introduction, reliable RSV surveillance should enable monitoring of vaccination impact. Data on the RSV disease burden in the European Union and European Economic Area (EU/EEA) are sparse.AimThe aim of this study was to gather knowledge on current practices of national RSV surveillance in the EU/EEA.MethodsNational Coordinators and National Focal Points for Influenza (epidemiologists and virologists) from the EU/EEA countries (n = 31) were invited to participate in an online survey in August and September 2017. The questionnaire covered questions on epidemiological and laboratory aspects of RSV surveillance.ResultsAll EU/EEA countries except Liechtenstein replied to the survey. Eighteen countries reported to have a sentinel surveillance system, 26 countries a non-sentinel surveillance system and three countries to have neither. RSV data collection was mostly done within the context of influenza surveillance. A wide range of diagnostic and characterisation assays was used for the detection of RSV.DiscussionThe majority of EU/EEA countries have some surveillance for RSV in place. The prevailing integration of RSV surveillance into the existing influenza sentinel surveillance system may lead to under-reporting of RSV. The documented variations in existing RSV surveillance systems and their outputs indicate that there is scope for developing guidelines on establishing comparable methods and outcomes for RSV surveillance across the EU/EEA, to ensure the availability of a consistent evidence base for assessing future vaccination programmes.
背景
呼吸道合胞病毒（RSV）是导致全球下呼吸道感染的主要病原体，目前有几种疫苗候选物正在开发中。疫苗接种后，可靠的 RSV 监测应能监测疫苗的接种效果。关于欧盟和欧洲经济区（EU/EEA）的 RSV 疾病负担的数据很少。
目的
本研究旨在收集欧盟/欧洲经济区（EU/EEA）国家目前进行 RSV 监测的实践知识。
方法
邀请欧盟/欧洲经济区（EU/EEA）国家的国家协调员和国家流感（传染病学家和病毒学家）联络点（n=31）参加 2017 年 8 月至 9 月的在线调查。问卷涵盖了 RSV 监测的流行病学和实验室方面的问题。
结果
除列支敦士登外，欧盟/欧洲经济区（EU/EEA）的所有国家都对调查做出了回应。18 个国家报告说有一个哨点监测系统，26 个国家有非哨点监测系统，3 个国家没有。RSV 数据收集主要是在流感监测的背景下进行的。广泛使用了各种诊断和特征分析检测方法来检测 RSV。
讨论
大多数欧盟/欧洲经济区（EU/EEA）国家都有一些针对 RSV 的监测。RSV 监测普遍纳入现有的流感哨点监测系统，可能导致 RSV 报告不足。现有 RSV 监测系统及其产出的记录差异表明，有必要制定在欧盟/欧洲经济区（EU/EEA）范围内建立可比的 RSV 监测方法和结果的指南，以确保为评估未来的疫苗接种计划提供一致的证据基础。
