Advanced Research Institute and Department of Chemistry, Taizhou University, Taizhou, Zhejiang 318000, P. R. China.
Org Biomol Chem. 2019 Oct 23;17(41):9209-9216. doi: 10.1039/c9ob01883b.
A highly efficient palladium-catalyzed arylation of azoles at the C2-position using 1-aryltriazenes as aryl reagents was developed. Azoles including oxazoles, thiazoles, imidazoles, 1,3,4-oxadiazoles, and oxazolines could react with 1-aryltriazenes smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.
开发了一种高效的钯催化唑类化合物 C2-芳基化反应，使用 1-芳基三氮唑作为芳基试剂。包括恶唑、噻唑、咪唑、1,3,4-恶二唑和恶唑啉在内的唑类化合物可以与 1-芳基三氮唑顺利反应，以良好至优秀的收率生成相应的产物，并且反应对各种取代模式具有耐受性。
