Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, South Korea.
PLoS One. 2019 Oct 9;14(10):e0223527. doi: 10.1371/journal.pone.0223527. eCollection 2019.
To investigate the changes in the demographic, clinical, and biometric characteristics of APAC patients in South Korea during the last decade.
Medical records of patients with APAC who visit the emergency department or the glaucoma clinic of Chonnam National University Hospital, a tertiary referral center in Gwangju, South Korea in 2007 and 2017 were analyzed. Demographics, clinical characteristics, and treatment modality were compared between the APAC patients in 2007 and 2017.
The number of patients with APAC increased from 54 in 2007 to 68 in 2017. Female patients in their 60s were most common in both groups and there was no significant difference in IOP, cataract grade, gonioscopic grading, PAS, or optic nerve damage between the two groups at baseline visit (all P > 0.05). However, APAC eyes in 2017 had a shallower ACD (1.74 ± 0.28 mm vs 1.87 ± 0.35 mm; P = 0.024) and greater LV (1.05 ± 0.26 mm vs 0.93 ± 0.19 mm; P = 0.001) than those of APAC eyes in 2007. During one year follow-up, 25 patients (51.02%) received LPI only, and 18 patients (36.73%) required LE, and 6 patients (12.24%) required phacotrabeculectomy or sequential LE and trabeculectomy. However, in 2017, LPI alone was sufficient in 23 patients (38.33%), 29 patients (48.33%) required further LE, and 8 patients (13.33%) required phacotrabeculectomy or sequential LE and trabeculectomy for the treatment of APAC (P = 0.015).
Compared to older cases of APAC, recent cases received LE more frequently, which suggests an increasing trend of LE as a treatment option for APAC. In addition, recent cases had a greater LV and shallower ACD than older cases and these biometric differences may be one of the reasons for increasing rate of LE in this study.
探讨过去十年间韩国亚太裔(APAC)患者的人口统计学、临床和生物测量特征的变化。
分析了 2007 年和 2017 年期间在韩国光州的三级转诊中心——全南国立大学医院的急诊室或青光眼诊所就诊的 APAC 患者的病历。比较了 2007 年和 2017 年 APAC 患者的人口统计学、临床特征和治疗方式。
APAC 患者的数量从 2007 年的 54 例增加到 2017 年的 68 例。两组中最常见的是 60 多岁的女性患者,两组在基线时的眼压(IOP)、白内障分级、房角分级、前房角渗出(PAS)或视神经损伤均无显著差异(均 P>0.05)。然而,2017 年的 APAC 眼的前房角深度(ACD)较浅(1.74±0.28mm 比 1.87±0.35mm;P=0.024),房角渗出容积(LV)较大(1.05±0.26mm 比 0.93±0.19mm;P=0.001)。在一年的随访期间,25 名患者(51.02%)仅接受小梁切开术(LPI),18 名患者(36.73%)需要小梁切除术(LE),6 名患者(12.24%)需要白内障超声乳化吸除术联合小梁切除术或序贯 LE 和小梁切除术。然而,在 2017 年,23 名患者(38.33%)仅接受 LPI 治疗即可,29 名患者(48.33%)需要进一步 LE,8 名患者(13.33%)需要白内障超声乳化吸除术联合小梁切除术或序贯 LE 和小梁切除术治疗 APAC(P=0.015)。
与较年长的 APAC 病例相比,最近的病例更频繁地接受 LE,这表明 LE 作为 APAC 治疗选择的趋势有所增加。此外,最近的病例的 LV 较大,ACD 较浅,与较年长的病例相比,这些生物测量差异可能是本研究中 LE 发生率增加的原因之一。