Fonterra Research and Development Centre, Dairy Farm Road, Private Bag 11029, Palmerston North 4442, New Zealand.
Department of Clinical Nutrition and Dietetics, College of Health Sciences, Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah 27272, UAE.
Nutrients. 2019 Oct 8;11(10):2400. doi: 10.3390/nu11102400.
Human milk oligosaccharides (HMOs), phospholipids (PLs), and gangliosides (GAs) are components of human breast milk that play important roles in the development of the rapidly growing infant. The differences in these components in human milk from the United Arab Emirates (UAE) were studied in a cross-sectional trial. High-performance liquid chromatography‒mass spectrometry was used to determine HMO, PL, and GA concentrations in transitional (5-15 days) and mature (at 6 months post-partum) breast milk of mothers of the United Arab Emirates (UAE). The results showed that the average HMO (12 species), PL (7 species), and GA (2 species) concentrations quantified in the UAE mothers' transitional milk samples were (in mg/L) 8204 ± 2389, 269 ± 89, and 21.18 ± 11.46, respectively, while in mature milk, the respective concentrations were (in mg/L) 3905 ± 1466, 220 ± 85, and 20.18 ± 9.75. The individual HMO concentrations measured in this study were all significantly higher in transitional milk than in mature milk, except for 3 fucosyllactose, which was higher in mature milk. In this study, secretor and non-secretor phenotype mothers showed no significant difference in the total HMO concentration. For the PL and GA components, changes in the individual PL and GA species distribution was observed between transitional milk and mature milk. However, the changes were within the ranges found in human milk from other regions.
人乳寡糖（HMOs）、磷脂（PLs）和神经节苷脂（GAs）是人乳中的成分，在快速生长的婴儿发育中发挥重要作用。本横断面研究旨在探讨阿联酋（UAE）人乳中这些成分的差异。采用高效液相色谱-质谱法测定阿联酋母亲的过渡乳（产后 5-15 天）和成熟乳（产后 6 个月）中 HMO、PL 和 GA 的浓度。结果显示，过渡乳中 HMO（12 种）、PL（7 种）和 GA（2 种）的平均浓度（mg/L）分别为 8204±2389、269±89 和 21.18±11.46，成熟乳中 HMO、PL 和 GA 的浓度（mg/L）分别为 3905±1466、220±85 和 20.18±9.75。除 3-岩藻糖基乳糖外，本研究中测定的个体 HMO 浓度在过渡乳中均显著高于成熟乳。在本研究中，分泌型和非分泌型表型母亲的总 HMO 浓度无显著差异。PL 和 GA 成分中，过渡乳和成熟乳中观察到各 PL 和 GA 种类分布的变化，但变化在其他地区人乳中发现的范围内。
