Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Nutrients. 2019 Oct 8;11(10):2404. doi: 10.3390/nu11102404.
Yingyangbao (YYB) is a nutrient-dense complementary food supplement for infants and young children in China. There has been considerable interest and research on the potential effects of YYB on hematological and anthropometric outcomes in China, but limited effort has been made to consolidate and synthesize the evidence to inform the research and policy agendas. Eight English databases and three Chinese databases were searched from January 2001 to June 2019 to identify YYB intervention studies. A total of 32 quasi-experimental, post-only, concurrent-control studies or pre-post studies were identified, and 26 were included in the meta-analyses. A pooled analysis of post-only studies with concurrent-control determined that YYB was associated with an increase of 4.43 g/L (95% confidence interval (CI) 1.55, 7.30) hemoglobin concentration, 2.46 cm (CI 0.96, 3.97) in height, and 0.79 kg (CI 0.25, 1.32) weight in infants and young children. YYB was also associated with reductions in the prevalence of anemia (risk ratio (RR) = 0.55; 95% CI: 0.45, 0.67), stunting (RR = 0.60; 95% CI: 0.44, 0.81), and underweight (RR = 0.51; 95% CI: 0.39, 0.65). Overall, YYB was found to be associated with improved hematological and anthropometric indicators among infants and young children in China; however, randomized trials are needed to causally assess the efficacy of YYB due to the inherent risk of bias in existing quasi-experimental studies; rigorous implementation and cost-effectiveness evaluations are also needed.
营养包是中国婴幼儿的一种营养密集型补充食品。在中国，人们对营养包对婴幼儿血液学和人体测量学结局的潜在影响产生了浓厚的兴趣并进行了大量研究，但却很少有人致力于整合和综合证据，以指导研究和政策议程。从 2001 年 1 月至 2019 年 6 月，我们检索了 8 个英文数据库和 3 个中文数据库，以确定营养包干预研究。共确定了 32 项准实验、仅后测、同期对照研究或前后测研究，其中 26 项被纳入荟萃分析。对同期对照的仅后测研究进行汇总分析发现，营养包可使婴幼儿血红蛋白浓度增加 4.43g/L（95%置信区间（CI）1.55，7.30），身高增加 2.46cm（CI 0.96，3.97），体重增加 0.79kg（CI 0.25，1.32）。营养包还与降低婴幼儿贫血患病率（风险比（RR）=0.55；95%CI：0.45，0.67）、生长迟缓率（RR=0.60；95%CI：0.44，0.81）和消瘦率（RR=0.51；95%CI：0.39，0.65）相关。总体而言，在中国，营养包与婴幼儿血液学和人体测量学指标的改善有关；然而，由于现有准实验研究存在固有偏倚风险，需要进行随机试验以确定营养包的疗效；还需要进行严格的实施和成本效益评估。
