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性别和性征对免疫和自身免疫的影响。

Sex and gender influence on immunity and autoimmunity.

机构信息

Hackensack Meridian School of Medicine, Hackensack, NJ, United States.

Institute for Autoimmune and Rheumatic Disease, St. Joseph Health, Wayne, NJ, United States.

出版信息

Front Immunol. 2023 May 26;14:1142723. doi: 10.3389/fimmu.2023.1142723. eCollection 2023.

DOI:10.3389/fimmu.2023.1142723
PMID:37304263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10250588/
Abstract

Autoimmune diseases are skewed toward one biological sex or another. This is the obvious observation of many decades, and it remains unexplained. Females predominate with most autoimmune diseases. The reasons for this predilection are an interplay of genetic, epigenetic and hormonal factors.

摘要

自身免疫性疾病偏向于某一性别。这是几十年来的明显观察结果，但仍未得到解释。大多数自身免疫性疾病中女性居多。这种偏好的原因是遗传、表观遗传和激素因素的相互作用。

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