Mekori Y A, Bender E M, Zapata-Sirvent R, Hansbrough J F, Claman H N
J Allergy Clin Immunol. 1985 Jul;76(1):90-6. doi: 10.1016/0091-6749(85)90809-7.
We studied the effects of H1 and H2 histamine receptor antagonists on down regulation of contact sensitivity (CS) to dinitrofluorobenzene (DNFB). Two H2 receptor antagonists, cimetidine and ranitidine, reversed the nonspecific immunosuppression of CS induced by burns. On the other hand, these two drugs did not affect the antigen-specific suppressor T cell-mediated tolerance to DNFB induced by dinitrobenzene sulfonic acid. Two H1 antagonists did not affect the down regulation of CS induced by either tolerance or burning. The differential sensitivities to histamine 2-receptor antagonists indicate that the mechanisms for nonspecific burn-induced immunosuppression are different from those for hapten-specific tolerance to DNFB.
我们研究了H1和H2组胺受体拮抗剂对二硝基氟苯（DNFB）接触敏感性（CS）下调的影响。两种H2受体拮抗剂西咪替丁和雷尼替丁，逆转了烧伤诱导的CS非特异性免疫抑制。另一方面，这两种药物不影响二硝基苯磺酸诱导的抗原特异性抑制性T细胞介导的对DNFB的耐受性。两种H1拮抗剂对耐受性或烧伤诱导的CS下调均无影响。对组胺2受体拮抗剂的不同敏感性表明，烧伤诱导的非特异性免疫抑制机制与对DNFB的半抗原特异性耐受性机制不同。
