Hyjazi Y, Maes E, Hurlet A, Masure R, Vekemans M
J Gynecol Obstet Biol Reprod (Paris). 1985;14(1):93-103.
Medroxyprogesterone acetate (MPA), a potent progestagen, is used as a very efficient contraceptive agent. The method of administration is by a threemonthly or sixmonthly intramuscular injection. The method is particularly convenient when the desired number of children has been reached. Fertility is sometimes reestablished only slowly after stopping the injections. The main side effects are linked to endometrial atrophy (blood loss, amenorrhoea). Other side effects are infrequent and subjective. A controversy has risen over the product, by reference to its effects on beagle dogs. We have reviewed the literature. We also present the characteristics of 313 patients treated during (all together) 8,000 months. These patients belong to a rather poor sample of the population (amongst them many immigrant women), aged about 30, with above average pregnancy and parity rates. We also studied, in 31 patients, serum levels of glucose and lipids, and haemostasis. Side effects and reasons for discontinuing the drug are reported. The Pearl index was 0,75% women-years. There was no average effect on weight, blood tension, glycemia. Triglycerides increased slightly, and there was a discreet activation of coagulation with inhibition of the fibrinolytic activity, but without clinical consequences. We conclude that we can go on prescribing the drug, in view of our study and after reviewing the literature.
醋酸甲羟孕酮（MPA）是一种强效孕激素，用作高效避孕药。给药方法是每三个月或每六个月进行一次肌肉注射。当达到期望的子女数量时，这种方法特别方便。停药后生育能力有时恢复缓慢。主要副作用与子宫内膜萎缩有关（失血、闭经）。其他副作用不常见且为主观感受。关于该产品对比格犬的影响引发了一场争议。我们查阅了文献。我们还呈现了313名患者在总共8000个月的治疗期间的特征。这些患者属于相当贫困的人群样本（其中有许多移民妇女），年龄约30岁，妊娠和产次率高于平均水平。我们还对31名患者的血糖、血脂水平及止血情况进行了研究。报告了副作用及停药原因。Pearl指数为0.75%妇女年。对体重、血压、血糖没有平均影响。甘油三酯略有升高，凝血有轻微激活且纤溶活性受到抑制，但无临床后果。鉴于我们的研究以及查阅文献后，我们得出结论，可以继续开具该药物的处方。
