Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, PR China.
Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, PR China.
Biomaterials. 2018 May;163:43-54. doi: 10.1016/j.biomaterials.2018.02.021. Epub 2018 Feb 8.
Photothermal therapy (PTT) is one of promising cancer therapy with high efficiency and minimal invasiveness. Exploiting of perfect PTT agent is vital to improve the therapy. In this study, a new type of bow tie-like molybdenum dioxide (MoO) nanoparticles was successfully synthesized. These nanobow-ties had strong localized surface plasmon resonance (SPR) effect from visible to near infrared regions, and exhibited ultrahigh chemical stability. They could not only withstand high temperature heating without oxidation, but also resist the corrosion of strong acid and alkali. Meanwhile, the MoO nanoparticles were highly stable in protein-containing biological medium, though they partly degraded in PBS solution. Both in vivo and in vitro experiments indicated that they exhibited inappreciable toxicity. Under illumination of near infrared laser, they showed excellent PTT effect, as revealed by significant inhibition of cancer cell viability in vitro and efficient destruction in tumor tissue growth in vivo. These MoO nanoparticles possessed highly chemical stability and low toxicity with high PTT efficiency, thus promising them high potential as nanoagent in cancer treatment.
光热疗法（PTT）是一种高效、微创的癌症治疗方法。开发完美的 PTT 试剂对于提高治疗效果至关重要。在本研究中，成功合成了一种新型的蝴蝶结状二氧化钼（MoO）纳米粒子。这些纳米蝴蝶结具有从可见光到近红外区域的强局域表面等离子体共振（SPR）效应，表现出超高的化学稳定性。它们不仅能承受高温加热而不被氧化，还能抵抗强酸和强碱的腐蚀。同时，MoO 纳米粒子在含有蛋白质的生物介质中高度稳定，尽管在 PBS 溶液中部分降解。体内和体外实验均表明，它们表现出可忽略的毒性。在近红外激光照射下，它们表现出优异的 PTT 效果，体外显著抑制癌细胞活力，体内有效破坏肿瘤组织生长。这些 MoO 纳米粒子具有高化学稳定性、低毒性和高光热转换效率，因此有望成为癌症治疗的纳米试剂。
