Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, People's Republic of China.
Christopher Ingold Laboratory, Department of Chemistry, University College London, London WC1H 0AJ, UK.
Nanoscale. 2017 Aug 10;9(31):11012-11016. doi: 10.1039/c7nr03469e.
Nanostructures of metal oxide semiconductors play significant roles in a variety of areas, such as biotherapy, pollutant treatment and energy storage and conversion. The molybdenum oxide (MoO) nanostructures have shown promising applications especially when used as photothermal treatment agents due to their relatively low cost, facile synthesis and low toxicity. However, the design and synthesis of efficient MoO nanomaterials with tunable phases and morphologies for theragnosis of tumors remains a challenge. In this work, hydrophilic MoO with controlled structures and phases was synthesized by a simple one-step hydrothermal process. The as-obtained MoO nanoclusters showed a desirable size of ∼40 nm in diameter exhibiting unique properties as a theragnosis nanoplatform: (1) strong near-infrared absorption, which is due to oxygen vacancies of the nanoclusters, as proved by photoluminescence spectroscopy and X-ray photoelectron spectroscopy; (2) excellent photothermal performance with a photothermal conversion efficiency of up to 62.1%; and (3) the image response of X-ray computed tomography (CT) and infrared thermal imaging for simultaneous diagnosis of tumors. This study provided the facile synthetic strategy for controllable metal oxide semiconductors and promoted the development of metal oxides for theragnosis therapy of cancers.
金属氧化物半导体的纳米结构在生物治疗、污染物处理以及能量存储和转换等多个领域发挥着重要作用。由于成本相对较低、合成简单且毒性低，氧化钼（MoO）纳米结构在用作光热治疗剂时显示出了很有前景的应用。然而，设计和合成具有可调相和形貌的高效 MoO 纳米材料，用于肿瘤的治疗和诊断仍然是一个挑战。在这项工作中，通过简单的一步水热法合成了具有可控结构和相的亲水性 MoO。所获得的 MoO 纳米团簇表现出独特的性质，直径约为 40nm，作为一种治疗和诊断的纳米平台：（1）强近红外吸收，这归因于纳米团簇中的氧空位，这一点通过光致发光光谱和 X 射线光电子能谱得到了证实；（2）优异的光热性能，光热转换效率高达 62.1%；（3）X 射线计算机断层扫描（CT）和红外热成像的图像响应，可用于肿瘤的同时诊断。这项研究为可控金属氧化物半导体的合成提供了简便的策略，并促进了金属氧化物在癌症治疗和诊断治疗中的发展。
