Koshikawa N, Smokcum R W, Stephenson J D
Neurosci Lett. 1985 Apr 19;55(3):279-82. doi: 10.1016/0304-3940(85)90448-3.
The 5-hydroxytryptamine (5-HT) uptake inhibitor, paroxetine (11.6 mg/kg i.p.), given to rats pretreated with the monoamine oxidase inhibitor, phenelzine, 18 h (46.8 mg/kg i.p.) and 90 min (11.7 mg/kg i.p.) before, evoked a 5-HT-dependent syndrome which included wet-dog shakes (WDS). The frequency of WDS declined over the ensuing 3 h, at which time cortical 5-HT2 receptors showed a significant (30%) decrease in number. A second injection of paroxetine given at this time did not evoke a significant increase in the number of WDS, suggesting that spinal 5HT2 receptors might also have been down-regulated at the same time.
5-羟色胺（5-HT）摄取抑制剂帕罗西汀（腹腔注射11.6毫克/千克），给予事先分别在18小时前（腹腔注射46.8毫克/千克）和90分钟前（腹腔注射11.7毫克/千克）接受单胺氧化酶抑制剂苯乙肼预处理的大鼠，引发了一种5-HT依赖性综合征，其中包括湿狗抖毛（WDS）。在随后的3小时内，WDS的频率下降，此时皮质5-HT2受体数量显著减少（30%）。此时再次注射帕罗西汀并未引起WDS数量的显著增加，这表明脊髓5HT2受体可能也在同一时间下调。
