School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Drug Discov Today. 2020 Jan;25(1):150-159. doi: 10.1016/j.drudis.2019.09.023. Epub 2019 Oct 7.
The inhaled delivery of nanomedicines has attracted much attention in the treatment of lung diseases or systemic diseases. However, there is a lack of understanding about their fate upon lung delivery. Thus, the objective of this review is to summarize physicochemical properties affecting the fate of nanoparticles after deposition in the lung. First, physiological structure and characteristics of the lung are described. Thereafter, physicochemical properties that could influence the clearance and translocation of nanoparticles in the lung are discussed, including particle size, surface charge and surface hydrophilicity. It is believed that, with a better understanding of the fate of nanoparticles in the lung, it will broaden their application in inhalation for a better therapeutic effect in the future.
吸入式纳米药物传递在肺部疾病或全身性疾病的治疗中受到了广泛关注。然而，人们对其在肺部给药后的命运缺乏了解。因此，本综述的目的是总结影响纳米颗粒在肺部沉积后命运的物理化学性质。首先，描述了肺部的生理结构和特征。然后，讨论了可能影响纳米颗粒在肺部清除和转移的物理化学性质，包括粒径、表面电荷和表面亲水性。相信通过更好地了解纳米颗粒在肺部的命运，将拓宽它们在吸入式给药中的应用，以在未来获得更好的治疗效果。
