Department of Internal Medicine, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Department of Cardiology, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Med Glas (Zenica). 2020 Feb 1;17(1):41-45. doi: 10.17392/1068-20.
Aim To study the anti-inflammatory effect of bay leaf on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model with myocardial infarction. Methods In the first phase, results of pathological examination and biochemical assay were compared between rats with and without induction of myocardial infarction. In the second phase, the effect of bay leaf extract on CRP and MPO of rats with myocardial infarction was studied. Results C-reactive protein and MPO were higher in rats which had myocardial infarction. Administration of bay leaf extract reduced levels of CRP and MPO in the rats started from day 4 after the induction of myocardial infarction. Conclusion Anti-inflammatory effect of bay leaf is confirmed, reflected by decreasing of CRP and MPO levels of rat model with myocardial infarction.
研究月桂叶对心肌梗死大鼠模型 C 反应蛋白（CRP）和髓过氧化物酶（MPO）水平的抗炎作用。
第一阶段，比较心肌梗死诱导前后大鼠的病理检查和生化检测结果。第二阶段，研究月桂叶提取物对心肌梗死大鼠 CRP 和 MPO 的影响。
发生心肌梗死的大鼠 CRP 和 MPO 水平较高。从心肌梗死诱导后第 4 天开始，给予月桂叶提取物可降低大鼠 CRP 和 MPO 水平。
通过降低心肌梗死大鼠模型的 CRP 和 MPO 水平，证实了月桂叶的抗炎作用。
