Wang Zhi-Fei, Rong Ping, Ma Rong, Xie Yan-Ming, Ding Ying, Wang Xue-Feng, Zhan Si-Yan, Li Xiu-Hui
Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381,China.
Zhongguo Zhong Yao Za Zhi. 2019 Jul;44(14):2932-2936. doi: 10.19540/j.cnki.cjcmm.20190521.502.
Xiyanping Injection is a commonly used medicine in clinical treatment,which is recommended by many pediatric disease guidelines/consensus. However,the instraction is relatively simple and lack of guidance for clinical application,which affects the efficacy and brings safety risks. Therefore,more detailed clinical guidance is urgently needed. This consensus is formulated by clinical experts of traditional Chinese medicine and Western medicine in pediatrics. This consensus follows Manual for the clinical experts consensus of Chinese patent medicine which published by China Association of Chinese Medicine. The study identified clinical problems using clinical investigation,searched the literature based on PICO clinical problems,using GRADE system to carry out evidences evaluation,classification and recommendation,and adopted the nominal grouping method to reach expert consensus. The consensus combines evidence-based evidence with expert experience,sufficient evidence of clinical problems would lead to " recommendations",and clinical problems with insufficient evidence will lead to " consensus suggestions". This expert consensus recommends the indications,intervention time for treatment,route of drug administration,dose conversion,the indications of being used alone,suitability and taboos of medicine combination,and introduces the safety and clinical application,to provide reference for clinical using.
喜炎平注射液是临床治疗中常用的药物，被多个儿科疾病指南/共识所推荐。然而，其说明书相对简单，缺乏临床应用指导，影响疗效并带来安全风险。因此，迫切需要更详细的临床指导。本共识由中西医结合的儿科临床专家制定。本共识遵循中华中医药学会发布的《中成药临床专家共识制定手册》。本研究通过临床调查确定临床问题，基于PICO临床问题检索文献，运用GRADE系统进行证据评价、分级和推荐，并采用名义组法达成专家共识。该共识将循证证据与专家经验相结合，临床问题证据充分的将形成“推荐意见”，证据不足的临床问题将形成“共识建议”。本专家共识对喜炎平注射液的适应证、治疗干预时机、给药途径、剂量换算、单独使用指征、药物联用的适宜性及禁忌等进行推荐，并介绍其安全性及临床应用情况，为临床使用提供参考。
