Mulas Fernando, Rojas Mildred, Gandía Rubén
Instituto Valenciano de Neurología Pediátrica (INVANEP), Valencia, España. E-mail:
Instituto Valenciano de Neurología Pediátrica (INVANEP), Valencia, España.
Medicina (B Aires). 2019;79 Suppl 3:33-36.
The development and establishment of the normal sleep patterns are very important processes in the final anatomical and physiological architecture of the central nervous system. The relationship between sleep disturbances during childhood with neurodevelopmental disorders is complex and potentially synergistic. Sleep patterns are present since the fetal period but their structure and physiology is modified according with the maturation of the central nervous system. Sleep disorders and their relationship with attention deficit hyperactivity disorders(ADHD), autism spectrum disorders(ASD) and other neurodevelopmental disorders (TDN) are not well understood yet, but significant progresses have been made in understanding associations and potential etiological correlations. We reviewed sleep disturbances in NDT, in ADHD and in ASD. A greater understanding of the pleiotropic functions of the genes involved in sleepwake cycle disorders and deviations from neurological developme nt could lead to new diagnostic and therapeut ic strategies in an early stage in order to improve the quality of life of the patient, relatives and caregivers.
正常睡眠模式的发展与确立是中枢神经系统最终解剖学和生理学结构中非常重要的过程。儿童期睡眠障碍与神经发育障碍之间的关系复杂且可能具有协同作用。睡眠模式自胎儿期就已存在，但其结构和生理学随着中枢神经系统的成熟而改变。睡眠障碍及其与注意力缺陷多动障碍（ADHD）、自闭症谱系障碍（ASD）和其他神经发育障碍（TDN）的关系尚未完全明了，但在理解关联和潜在病因相关性方面已取得显著进展。我们综述了神经发育障碍、ADHD和ASD中的睡眠障碍。更深入了解参与睡眠 - 觉醒周期障碍的基因的多效性功能以及与神经发育偏差的关系，可能会在早期阶段带来新的诊断和治疗策略，以提高患者、亲属和照料者的生活质量。
