Chen Chen, Shen Yi-Dong, Xun Guang-Lei, Cai Wei-Xiong, Shi Li-Juan, Xiao Lu, Wu Ren-Rong, Zhao Jing-Ping, Ou Jian-Jun
Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, P.R.China, GuangFu West Road 1347#, Shanghai 200063, People's Republic of China.
Mental Health Institute of the Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
Autism Res. 2017 Jun;10(6):1155-1162. doi: 10.1002/aur.1751. Epub 2017 Mar 7.
Aggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study. The Institute for Basic Research - Modified Overt Aggression Scale (IBR-MOAS) was used to assess aggressive behaviors. Children's social impairments, sleep problems and ADHD symptoms were also measured with specific scales. The total IBR-MOAS score was significantly higher (worse) in the TD group [4.47 (5.36)] than in the ASD group [3.47 (5.63), P = 0.004]. The aggressive modes differed between groups: when compared with each other, the TD group received higher scores on Verbal and Physical Aggression Toward Others (all P < 0.01), while the ASD group had higher scores on Physical Aggression Against Self (P = 0.006). The linear regression model demonstrated that the aggressive behaviors of children with ASD were significantly associated with two treatable factors: sleep problems and ADHD symptoms. These findings have substantial clinical implications: treatment of these two risk factors may be helpful in managing aggressive behavior in children with ASD. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1155-1162. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.
自闭症谱系障碍（ASD）儿童的攻击性行为很常见。我们开展这项研究以描述患有ASD的学龄前儿童的攻击模式，并研究特定攻击行为与两个可治疗因素之间的关联：睡眠问题和注意力缺陷多动障碍（ADHD）症状。本研究共调查了577名发育正常（TD）儿童和490名患有ASD的儿童。使用基础研究机构改良的公开攻击量表（IBR-MOAS）评估攻击行为。还使用特定量表测量了儿童的社交障碍、睡眠问题和ADHD症状。TD组的IBR-MOAS总分[4.47（5.36）]显著高于ASD组[3.47（5.63），P = 0.004]。两组的攻击模式有所不同：相互比较时，TD组在对他人的言语攻击和身体攻击方面得分更高（所有P < 0.01），而ASD组在针对自身的身体攻击方面得分更高（P = 0.006）。线性回归模型表明，患有ASD的儿童的攻击行为与两个可治疗因素显著相关：睡眠问题和ADHD症状。这些发现具有重要的临床意义：治疗这两个风险因素可能有助于管理患有ASD的儿童的攻击行为。《自闭症研究》2017年。©2017国际自闭症研究协会，威利期刊公司。《自闭症研究》2017年，10: 1155 - 1162。©2017国际自闭症研究协会，威利期刊公司。
