关于类动力蛋白活性在三维滑动丝模型中对扭转的作用。
On the contribution of dynein-like activity to twisting in a three-dimensional sliding filament model.
作者信息
Hines M, Blum J J
出版信息
Biophys J. 1985 May;47(5):705-8. doi: 10.1016/S0006-3495(85)83967-9.
It has been shown (Hines, M., and J. J. Blum, Biophys.J., 1984, 46:559-565) that passive moment-bearing links do not contribute appreciable twist resistance to an axoneme nor do they cause appreciable twisting in response to internal shear forces. We now examine the contribution of active moment-bearing links such as dynein arms to the generation of twist within an axoneme. The dynein model used causes distal sliding of the adjacent doublet by a force dependent on the angle of attachment of the arms. Attachment of the arms occurs at a specified angle relative to the angle of minimum potential energy. The steady state shape consistent with the forces applied by the attached dyneins is computed. It is shown that the twist generated in an active region is counterclockwise as viewed from tip to base and therefore accumulates at the end of the axoneme. For realistic forces and twist resistances, cumulative twist should not exceed a few degrees.
已经表明（海因斯，M.，和J. J. 布卢姆，《生物物理杂志》，1984年，46:559 - 565），被动承载力矩的连接对轴丝的抗扭转贡献不大，并且它们也不会因内部剪切力而产生明显的扭转。我们现在研究诸如动力蛋白臂等主动承载力矩的连接对轴丝内扭转产生的贡献。所使用的动力蛋白模型通过一个取决于臂附着角度的力使相邻的双联体发生远端滑动。臂的附着相对于最小势能角度以特定角度发生。计算出与附着的动力蛋白所施加的力一致的稳态形状。结果表明，从尖端到基部观察，在活动区域产生的扭转是逆时针的，因此在轴丝末端积累。对于实际的力和抗扭转能力，累积扭转不应超过几度。
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