产生运动的横桥的计算机模拟
Computer simulation of movement-generating cross-bridges.
作者信息
Brokaw C J
出版信息
Biophys J. 1976 Sep;16(9):1013-27. doi: 10.1016/S0006-3495(76)85752-9.
Abstract
A stochastic computational method was developed to study properties of cross-bridge models for muscle contraction, by following the time history of individual cross-bridge model of Andrew Huxley (1957) and a modified two-state model with more realistic behavior during steady stretching are used as examples. The method can readily compute steady-state force during shortening and stretching and force-transients following rapid changes in length. Computations of velocity with a steady load and of velocity transients are more sensitive to the randomness inherent in the stochastic method.
摘要
开发了一种随机计算方法，以研究肌肉收缩的横桥模型的特性，以安德鲁·赫胥黎（1957年）的单个横桥模型的时间历程为例，并使用了一种在稳定拉伸期间具有更真实行为的改进双态模型。该方法可以很容易地计算缩短和拉伸过程中的稳态力以及长度快速变化后的力瞬变。在恒定负载下计算速度和速度瞬变对随机方法中固有的随机性更为敏感。
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