Bromley Steven M, Doty Richard L
South Jersey MS Center and Bromley Neurology, PC Audubon, NJ, United States.
Smell and Taste Center and Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Handb Clin Neurol. 2019;164:219-227. doi: 10.1016/B978-0-444-63855-7.00014-9.
Key elements for understanding, assessing, and treating a patient with a complaint of chemosensory dysfunction include establishing a relevant medical history and performing a focused medical examination. This age-old medical approach combines the utilization of associated tests and the results of chemosensory testing to establish a diagnosis and plan for medical management. Chemosensory testing is critical to establish the degree of dysfunction, the veracity and accuracy of a patient's self-report, the efficacy of treatments, and the degree to which spontaneous recovery occurs. In common with most medical disorders, it is incumbent upon the physician to determine, as best as possible, the time of onset of the symptom, its severity, precipitating factors, comorbidities, and fluctuations over time to understand the underlying pathophysiology. Importantly, distinguishing between "taste" loss due to decreased flavor sensations secondary to olfactory system compromise and "taste" loss due to true taste bud-mediated sensory alterations is critical. Unfortunately, this distinction is often underappreciated by medical professionals and laypersons alike, resulting in needless referrals within the medical community, including those related to imaging and gastroenterological testing. This chapter outlines the basic elements of the medical history and assessment of patients with complaints of chemosensory dysfunction, including a discussion on how to detect malingering.
理解、评估和治疗主诉化学感觉功能障碍患者的关键要素包括建立相关病史并进行针对性的体格检查。这种古老的医学方法结合了相关检查的运用以及化学感觉测试的结果,以确立诊断并制定医疗管理计划。化学感觉测试对于确定功能障碍的程度、患者自我报告的真实性和准确性、治疗效果以及自发恢复的程度至关重要。与大多数医学病症一样,医生有责任尽可能确定症状的发作时间、严重程度、诱发因素、合并症以及随时间的波动情况,以了解潜在的病理生理学。重要的是,区分因嗅觉系统受损导致味觉感受减退引起的“味觉”丧失和因真正的味蕾介导的感觉改变引起的“味觉”丧失至关重要。不幸的是,这种区别往往未得到医学专业人员和外行人的充分重视,导致在医疗界进行不必要的转诊,包括那些与影像学和胃肠病学检查相关的转诊。本章概述了主诉化学感觉功能障碍患者的病史和评估的基本要素,包括关于如何检测伪装的讨论。