Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Hebei Academy of Chinese Medicine Sciences, Shijiazhuang, Hebei, China.
PLoS One. 2024 Mar 22;19(3):e0300935. doi: 10.1371/journal.pone.0300935. eCollection 2024.
This study aims to investigate the relationship between taste dysfunction and depression among patients with schizophrenia, to achieve early detection of depression in clinical practice.
Following PRISMA guidance, a comprehensive literature search was conducted globally, covering papers published from 1961 to June 2023. A total of 17 manuscripts were selected through meta-analysis and sensitivity analysis after examining available materials from seven databases to determine the correlation between depression and taste dysfunction.
The comparison of the 17 selected manuscripts revealed that individuals with gustatory dysfunction may be more likely to experience depressive symptoms (SMD, 0.51, 95% CI, 0.08 to 0.93, p = 0.02). Depression is associated with taste dysfunction in certain aspects, as indicated by the pleasantness ratings of sucrose solutions (SMD, -0.53, 95% confidence interval [CI] -1.11 to 0.05, p = 0.08), gustatory identification ability (SMD, 0.96, 95% CI, 0.03 to 1.89, p = 0.04), and the perception threshold of sweet taste (MD, 0.80, 95% CI, 0.79 to 0.81, p < 0.00001).
Due to variations in the methods, designs, and selection criteria employed in the included studies, it is necessary to establish a feasible framework. Future research using detailed and targeted approaches can provide clearer and more unified conclusions on the relationship between taste dysfunction and depression. Moreover, further high-quality research is needed to obtain clearer conclusions and explore the potential of taste dysfunction as an effective tool for early screening of depression.
This review has been registered in the PROSPERO on April 2022 with the identifier CRD42023400172.
本研究旨在探讨精神分裂症患者味觉障碍与抑郁之间的关系，以期在临床实践中实现抑郁的早期检测。
根据 PRISMA 指南，对全球范围内的文献进行了全面检索，检索范围涵盖了 1961 年至 2023 年 6 月发表的文献。通过对来自 7 个数据库的现有资料进行元分析和敏感性分析，共选取了 17 篇文献，以确定抑郁与味觉障碍之间的相关性。
对这 17 篇选定文献的比较表明，味觉障碍患者可能更容易出现抑郁症状（SMD，0.51，95%置信区间，0.08 至 0.93，p = 0.02）。某些方面的抑郁与味觉障碍有关，如蔗糖溶液的愉悦度评分（SMD，-0.53，95%置信区间[-1.11，0.05]，p = 0.08）、味觉识别能力（SMD，0.96，95%置信区间[0.03，1.89]，p = 0.04）和甜味感知阈值（MD，0.80，95%置信区间[0.79，0.81]，p < 0.00001）。
由于纳入研究的方法、设计和选择标准存在差异，因此有必要建立一个可行的框架。未来使用详细和针对性方法的研究可以提供更清晰和更统一的关于味觉障碍和抑郁之间关系的结论。此外，还需要进一步进行高质量的研究，以获得更清晰的结论，并探讨味觉障碍作为早期筛查抑郁的有效工具的潜力。
本综述于 2022 年 4 月在 PROSPERO 上注册，标识符为 CRD42023400172。
