Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Brain Behav Immun. 2020 Jan;83:293-297. doi: 10.1016/j.bbi.2019.10.008. Epub 2019 Oct 10.
Autism Spectrum Disorders (ASD) are complex and multifactorial. Previous investigations have revealed associations between allergic disease and ASD, which are characterized by impaired communication skills. In this study we observed an association between allergic disease and communication skills development as assessed by the Ages and Stages Questionnaire (ASQ) communication score, as a proxy for ASD, among children who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In particular, we observed significant associations between both a diagnosis of eczema at age 3 years (OR = 1.87; confidence interval [CI]: 0.97-3.47; p = 0.054) and a diagnosis of food allergy at age 6 years (OR = 3.61; 95% CI: 1.18-9.85; p = 0.015) with ASQ communication score. Plasma metabolomics analyses suggest that dysregulated tryptophan metabolism may contribute to the pathogenesis of these co-morbidities.
自闭症谱系障碍（ASD）是一种复杂的多因素疾病。先前的研究表明，过敏疾病与 ASD 之间存在关联，而 ASD 的特征是沟通技能受损。在这项研究中，我们观察到维生素 D 产前哮喘减少试验（VDAART）中，过敏疾病与 Ages and Stages Questionnaire（ASQ）沟通评分（ASD 的替代指标）之间存在关联，ASQ 沟通评分反映了儿童沟通技能的发展情况。具体而言，我们观察到 3 岁时患有湿疹（OR=1.87；95%置信区间：0.97-3.47；p=0.054）和 6 岁时患有食物过敏（OR=3.61；95%置信区间：1.18-9.85；p=0.015）的诊断与 ASQ 沟通评分显著相关。血浆代谢组学分析表明，色氨酸代谢失调可能导致这些共病的发病机制。
