Herbal Medicine Research Division Korea Institute of Oriental Medicine, Daejeon, 34054, South Korea.
College of Veterinary Medicine, Chungnam National University, Daejeon, 34134, South Korea.
J Ethnopharmacol. 2020 Feb 10;248:112300. doi: 10.1016/j.jep.2019.112300. Epub 2019 Oct 10.
Mahuang-Tang (MHT) has traditionally been used in Asia to treat a variety of diseases, such as fever without sweating, joint pain, lower back pain, asthma, and gynecological conditions. Polycystic ovary syndrome (PCOS) is a kind of gynecological disease that causes amenorrhea, infertility, and menopausal and urogenital disorders that could benefit from MHT treatment.
In this study, we examined the effects of MHT on ovarian hormones and steroidogenic enzymes in female PCOS rats.
The PCOS rat model was induced by Letrozole, and an in vivo evaluation of whether the dietary consumption of MHT improved the PCOS-like symptoms was conducted. The luteinizing hormone (LH) level and luteinizing hormone/follicular-stimulating hormone (LH/FSH) ratio increased in PCOS rats but decreased following MHT treatment. In the PCOS rats, the reduced estrogen level was restored to that of normal controls with MHT treatment in serum. The transcription level(s) of gonadotropin receptors (Fshr and Lhr), steroid receptors (Pgr, and Esr1) and steroidogenic enzymes (Cyp19a1, Hsd3b1, Hsd17a1, and Cyp11a1) changed under the PCOS condition, and were regulated by MHT treatment in the ovaries of PCOS rats. The reproductive tissues of Letrozole-induced PCOS rats were restored into estrogenic condition from androgen environments.
These results suggest that MHT ameliorates the symptoms of PCOS by improving the dysregulation of ovarian steroids and steroidogenic enzymes in PCOS rats.
麻黄汤（MHT）在亚洲传统上被用于治疗各种疾病，如无汗发热、关节痛、腰痛、哮喘和妇科疾病。多囊卵巢综合征（PCOS）是一种妇科疾病，可导致闭经、不孕以及绝经和泌尿生殖系统紊乱，可受益于 MHT 治疗。
本研究旨在探讨 MHT 对多囊卵巢综合征大鼠卵巢激素和类固醇生成酶的影响。
用来曲唑诱导 PCOS 大鼠模型，并进行体内评价，观察 MHT 饮食是否改善 PCOS 样症状。促黄体生成素（LH）水平和 LH/卵泡刺激素（LH/FSH）比值在 PCOS 大鼠中升高，但 MHT 治疗后降低。在 PCOS 大鼠中，MHT 治疗可使血清中降低的雌激素水平恢复到正常对照水平。促性腺激素受体（Fshr 和 Lhr）、类固醇受体（Pgr 和 Esr1）和类固醇生成酶（Cyp19a1、Hsd3b1、Hsd17a1 和 Cyp11a1）的转录水平在 PCOS 状态下发生变化，MHT 治疗可调节 PCOS 大鼠卵巢中这些基因的表达。来曲唑诱导的 PCOS 大鼠的生殖组织从雄激素环境恢复到雌激素状态。
这些结果表明，MHT 通过改善 PCOS 大鼠卵巢类固醇和类固醇生成酶的失调来改善 PCOS 的症状。
