Pedlow Katy, McDonough Suzanne, Lennon Sheila, Kerr Claire, Bradbury Ian
Centre for Health and Rehabilitation Technologies (CHaRT), Institute of Nursing and Health Research, Ulster University, Room 1F110, Shore Road, Newtownabbey, County Antrim, UK, BT37 OQB.
Cochrane Database Syst Rev. 2019 Oct 13;10(10):CD011550. doi: 10.1002/14651858.CD011550.pub2.
Duchenne muscular dystrophy (DMD) is the most common X-linked neuromuscular disorder. When boys with DMD reach the second decade of life, they lose their ability to walk and become wheelchair dependent. Standing devices and orthoses are considered to be an essential component in the therapy management of DMD. Clinical opinion and research from other neurological conditions highlight the proposed benefits of standing device use, however, its effect within this population is currently unknown. A review of the evidence for the use of standing devices and orthoses is necessary to inform all stakeholders, including people with DMD, clinicians, decision makers and funders, and to guide future research.
To assess the effects of standing devices and orthoses on musculoskeletal impairments (such as pain, contracture, scoliosis development and bone density) in boys and men with DMD, and secondarily to determine their effect on quality of life, participation in activities, and patient experience (satisfaction). We also considered any adverse events associated with their use.
We searched the Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE, Embase, AMED, PsycINFO, CINAHL Plus, PEDro, and ProQuest Dissertations & Theses Global up to 5 September 2019. We checked references in identified trials, handsearched journal abstracts, and searched trials registries.
We planned to include randomised controlled trials (RCTs) and quasi-RCTs of any model of standing device for use in DMD. The control interventions would have been any other comparison group, including no standing device, a different model of standing device, usual care, or an alternative form of assistive weight bearing.
We used standard Cochrane methodological procedures.
Although we identified 13 potentially relevant studies, none met the inclusion criteria for this review.
AUTHORS' CONCLUSIONS: Since there were no RCTs or quasi-RCTs available to evaluate the effectiveness of standing devices in people with DMD, studies are needed to investigate the effectiveness of standing devices in this population.
杜氏肌营养不良症（DMD）是最常见的X连锁神经肌肉疾病。患有DMD的男孩到第二个十年时，会失去行走能力，只能依靠轮椅。站立设备和矫形器被认为是DMD治疗管理的重要组成部分。来自其他神经系统疾病的临床观点和研究强调了使用站立设备的潜在益处，然而，其在该人群中的效果目前尚不清楚。有必要对使用站立设备和矫形器的证据进行综述，以便为包括DMD患者、临床医生、决策者和资助者在内的所有利益相关者提供信息，并指导未来的研究。
评估站立设备和矫形器对患有DMD的男孩和男性肌肉骨骼损伤（如疼痛、挛缩、脊柱侧弯发展和骨密度）的影响，其次确定它们对生活质量、参与活动和患者体验（满意度）的影响。我们还考虑了与使用它们相关的任何不良事件。
我们检索了Cochrane神经肌肉专业注册库、CENTRAL、MEDLINE、Embase、AMED、PsycINFO、CINAHL Plus、PEDro以及ProQuest Dissertations & Theses Global，检索截至2019年9月5日。我们检查了已识别试验中的参考文献，手工检索了期刊摘要，并检索了试验注册库。
我们计划纳入任何用于DMD的站立设备模型的随机对照试验（RCT）和半随机对照试验。对照干预措施将是任何其他比较组，包括不使用站立设备、不同型号的站立设备、常规护理或辅助负重的替代形式。
我们使用了标准的Cochrane方法学程序。
尽管我们识别出13项可能相关的研究，但没有一项符合本综述的纳入标准。
由于没有RCT或半随机对照试验可用于评估站立设备对DMD患者的有效性，因此需要进行研究来调查站立设备在该人群中的有效性。
