Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Department of Gastroenterology, First Hospital of Yangtze University, Yangtze University, Jingzhou, China.
Neoplasma. 2019 Nov;66(6):896-907. doi: 10.4149/neo_2019_190119N59. Epub 2019 Oct 8.
Malic enzyme 3 (ME3) aberrant expression contributes to the development of human malignancies. ME3 expression was higher in pancreatic cancer tissues than that in non-tumor tissues, and patients with higher ME3 levels had significantly shorter survival than those with lower levels analyzed by of Badea and TCGA databases. Further, the abilities of proliferation, migration and invasion in pancreatic cancer cells were inhibited by ME3 knockdown and were promoted by ME3 overexpression. Meanwhile, ME3 can promote EMT in pancreatic cancer cells possibly by regulation of TGF-β/Smad2/3 signaling pathway. In conclusion, ME3 is extensively involved in carcinogenesis of pancreatic cancer and may become a new candidate target for diagnosis, treatment and prognosis of pancreatic cancer.
苹果酸酶 3（ME3）异常表达有助于人类恶性肿瘤的发展。ME3 在胰腺癌组织中的表达高于非肿瘤组织，Badea 和 TCGA 数据库分析表明，ME3 水平较高的患者的生存时间明显短于 ME3 水平较低的患者。此外，ME3 敲低抑制胰腺癌细胞的增殖、迁移和侵袭能力，而 ME3 过表达则促进其能力。同时，ME3 可能通过调节 TGF-β/Smad2/3 信号通路促进胰腺癌细胞的 EMT。总之，ME3 广泛参与胰腺癌的发生，可能成为胰腺癌诊断、治疗和预后的新候选靶点。
