Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Amphur Klongluang, Thailand.
Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
J Cosmet Dermatol. 2020 Jun;19(6):1432-1438. doi: 10.1111/jocd.13183. Epub 2019 Oct 14.
Xerosis is a common problem among the elderly, characterized by dry-scaling erythema, fissuring, or pruritus, which could be treated by anti-inflammatory moisturizers without side effects of steroids.
We aimed to investigate the efficacy of anti-inflammatory moisturizer (MAS062D lotion) vs hydrophilic cream for the improvement of dry and barrier function skin in xerosis patients.
A split site, triple-blinded, randomized, controlled trial was conducted in the elderly with moderate to severe xerosis, who received the 28-day twice daily application of MAS062D lotion and hydrophilic cream on the assigned shins. The evaluations on day 0, 14, and 28 were performed using clinical assessment, skin hydration by corneometer, transepidermal water loss (TEWL), and biometric assessment.
There were 24 Thai elderly patients, of whom 87.5% were female (mean age = 58.04 years and mean xerosis severity scale (XSS) = 4.83). Both treatments revealed similar statistically significant improvement in XSS (P < .001). Interestingly, MAS062D lotion-treated side remarkably showed improvement of skin hydration compared with hydrophilic-treated side for 26.86 ± 7.94 vs 25.84 ± 5.1, 41.24 ± 6.92 vs 20.96 ± 6.8, 50.49 ± 8.2 vs 21.75 ± 8.29 at baseline, day 14, and 28, respectively (P-value < .001). Moreover, MAS062D lotion significantly yielded greater decrease in TEWL measurement and more erythema improvement than hydrophilic cream (P-value < .001). No serious adverse effects were observed with either treatment.
The MAS062D lotion could potentially be an efficacious treatment for improvement of xerosis in the elderly, which is also safe and refrains from steroid side effects.
干燥症是老年人中常见的问题，其特征为干燥、红斑、皲裂或瘙痒，可以使用具有抗炎作用的保湿剂进行治疗，且无类固醇的副作用。
我们旨在研究抗炎保湿剂（MAS062D 乳液）与亲水性乳膏对干燥症患者皮肤干燥和屏障功能改善的疗效。
一项在患有中重度干燥症的老年人中进行的、采用Split-site、三盲、随机、对照临床试验，这些老年人在双侧小腿上接受了为期 28 天、每天两次应用 MAS062D 乳液和亲水性乳膏的治疗。在第 0、14 和 28 天进行临床评估、皮肤水分测量（Corneometer）、经皮水分丢失（TEWL）和生物计量评估。
共有 24 名泰国老年人患者入组，其中 87.5%为女性（平均年龄为 58.04 岁，干燥严重程度评分（XSS）平均为 4.83）。两种治疗方法均显示 XSS 显著改善（P<0.001）。有趣的是，MAS062D 乳液治疗侧的皮肤水分明显优于亲水性乳膏治疗侧，在基线、第 14 天和第 28 天，MAS062D 乳液治疗侧的皮肤水分分别为 26.86±7.94、41.24±6.92 和 50.49±8.2，而亲水性乳膏治疗侧的皮肤水分分别为 25.84±5.1、20.96±6.8 和 21.75±8.29（P 值均<.001）。此外，MAS062D 乳液在 TEWL 测量值降低和红斑改善方面均显著优于亲水性乳膏（P 值均<.001）。两种治疗均未观察到严重不良反应。
MAS062D 乳液可能是治疗老年人干燥症的有效方法，且安全，无类固醇的副作用。
