Bora Larisa, Iftode Andrada, Muț Ana Maria, Vlaia Lavinia Lia, Olteanu Gheorghe-Emilian, Muntean Delia, Dehelean Cristina Adriana, Buda Valentina, Coneac Georgeta Hermina, Danciu Corina
Department of Pharmacognosy, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Research Center for Pharmaco-Toxicological Evaluation, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Pharmaceuticals (Basel). 2023 Jul 8;16(7):980. doi: 10.3390/ph16070980.
Skin tags, also known as fibroepithelial polyps (FPs) or acrochordons, are soft, pigmented excrescences, with a prevalence of 50-60% in the population, occurring especially in the fourth decade of life. To date, FPs have been efficiently eliminated using minimum invasive methods such as surgical removal, cauterization, laser irradiation, and cryosurgery. Over-the-counter treatments are also of interest for patients due to their non-invasive character, but their clinical efficiency has not been clearly demonstrated. This study was designed in order to evaluate the efficacy of a modern-pharmaceutical-formulation-type poloxamer-based binary hydrogel, having L. essential oil (OEO-PbH) as an active ingredient in the management of FPs. The formulation has been shown to possess good qualities in terms of stability and sterility. Non-invasive measurements revealed changes in some physiological skin parameters. An increase in transepidermal water loss (TEWL) and erythema index was noted, while skin surface water content (SWC) decreased during eight weeks of treatment. The macroscopic evaluation revealed that the FPs dried and shrunk after topical treatment with OEO-PbH. Clinically, patients presented a lowering of the number of lesions on the treated area of 20-30% after one month of treatment and around 50% after the second month. Histopathological examination suggests that topical treatment with OEO-PbH may induce histological changes in the epidermis, dermis, and fibrovascular cores of FPs, including a loss of thickness, reduced size and number of blood vessels, and low cellularity. These changes may contribute to the observed reduction in size of FPs after treatment with OEO-PbH.
皮赘，也被称为纤维上皮性息肉（FPs）或软垂疣，是一种柔软的、有色素沉着的赘生物，在人群中的患病率为50%-60%，尤其在人生的第四个十年出现。迄今为止，已经使用手术切除、烧灼、激光照射和冷冻手术等微创方法有效地消除了FPs。非处方治疗因其非侵入性的特点也受到患者的关注，但其临床疗效尚未得到明确证实。本研究旨在评估一种现代药物制剂类型的基于泊洛沙姆的二元水凝胶的疗效，该水凝胶以柠檬香茅精油（OEO-PbH）作为治疗FPs的活性成分。该制剂在稳定性和无菌性方面已显示出良好的特性。非侵入性测量揭示了一些生理皮肤参数的变化。在治疗的八周内，经表皮水分流失（TEWL）和红斑指数增加，而皮肤表面含水量（SWC）下降。宏观评估显示，用OEO-PbH局部治疗后，FPs干燥并缩小。临床上，治疗一个月后，患者治疗区域的病变数量减少了20%-30%，第二个月后减少了约50%。组织病理学检查表明，用OEO-PbH局部治疗可能会引起FPs的表皮、真皮和纤维血管核心的组织学变化，包括厚度减少、血管大小和数量减少以及细胞密度降低。这些变化可能导致用OEO-PbH治疗后观察到的FPs尺寸减小。
