Reddy K Nagarjuna, Chary D Yogananda, Sridhar B, Reddy B V Subba
Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110025 , India.
Org Lett. 2019 Nov 1;21(21):8548-8552. doi: 10.1021/acs.orglett.9b03041. Epub 2019 Oct 14.
An efficient Rh(III)-catalyzed bicyclization of 2-arylimidazo[1,2-]pyridine with cyclic enones has been developed for the synthesis of bridged imidazopyridine derivatives in excellent yields up to 95%. The reaction proceeds through a sequential conjugate addition of -C-H bond of aryl group followed by an intramolecular C3-alkylation of imidazopyridine ring in a highly regioselective manner.
已开发出一种高效的铑（III）催化的2-芳基咪唑并[1,2 - ]吡啶与环状烯酮的双环化反应，用于合成桥连咪唑并吡啶衍生物，产率高达95%，效果优异。该反应通过芳基的 -C-H键依次进行共轭加成，然后以高度区域选择性的方式进行咪唑并吡啶环的分子内C3-烷基化反应。
