Battula Shravani, Bukya Hemalatha, Chandra Shekar Kunta, Nayani Kiranmai
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
J Org Chem. 2023 Aug 4;88(15):10986-10995. doi: 10.1021/acs.joc.3c00960. Epub 2023 Jul 25.
A Rh(III)-catalyzed annulation of 2-arylimidazo[1,2-]pyridines with -quinols has been realized, leading to bridged heterocycles with three contiguous stereocenters via a twofold conjugate addition. The cascade reaction is diastereoselective and proceeds through a sequential Rh-catalyzed C(sp)-H functionalization of the aryl group of imidazo[1,2-]pyridine with -quinol followed by an intramolecular conjugate addition to provide a series of diverse, novel bridged heterocycles.
已实现铑（III）催化的2-芳基咪唑并[1,2 - ]吡啶与喹诺醇的环化反应，通过双重共轭加成生成具有三个相邻立体中心的桥连杂环。该串联反应具有非对映选择性，通过铑催化的咪唑并[1,2 - ]吡啶芳基与喹诺醇的C(sp)-H官能团化，随后进行分子内共轭加成，从而提供一系列多样的新型桥连杂环。
